Evidence map›Paper›PMID 39233852›Full record

ArticleMolecular therapy. Nucleic acids2024

Identification of selective and non-selective

James W Gilbert, Zachary Kennedy, Bruno M D C Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, David Cooper, Ken Yamada and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Genetic therapies for neurological diseases.Pharmacological reviews · 2026
    Review
  3. Article
  4. Article
  5. Chemical Modifications in Nucleic Acid Therapeutics.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

James W GilbertRNA Therapeutic Institute, Worcester, MA 01655, USA.
Zachary KennedyRNA Therapeutic Institute, Worcester, MA 01655, USA.
Bruno M D C GodinhoRNA Therapeutic Institute, Worcester, MA 01655, USA.
Ashley SummersRNA Therapeutic Institute, Worcester, MA 01655, USA.
Alexandra WeissDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Dimas EcheverriaRNA Therapeutic Institute, Worcester, MA 01655, USA.
Brianna BramatoRNA Therapeutic Institute, Worcester, MA 01655, USA.
Nicholas McHughRNA Therapeutic Institute, Worcester, MA 01655, USA.
David CooperRNA Therapeutic Institute, Worcester, MA 01655, USA.
Ken YamadaRNA Therapeutic Institute, Worcester, MA 01655, USA.
Matthew HasslerRNA Therapeutic Institute, Worcester, MA 01655, USA.
Hélène TranDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Fen Biao GaoRNA Therapeutic Institute, Worcester, MA 01655, USA.
Robert H BrownDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Anastasia KhvorovaRNA Therapeutic Institute, Worcester, MA 01655, USA.

Funding

Expanding the chemical diversity of therapeutic oligonucleotides to treat neurodegenerative disordersR01NS104022 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANASTASIA KHVOROVA · 2017 to 2026
$6.0M
Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
NINDS NIH HHS R01 NS104022NINDS NIH HHS R37 NS057553
6 · The paper itself

Abstract

A hexanucleotide (G

Indexed as

C9ORF72 amyotrophic lateral sclerosis, ALSdipeptide-repeat proteinsfrontotemporal dementia, FTDmRNA localizationMT: Oligonucleotides: Therapies and Applicationsoligonucleotide therapeuticssiRNA

Identifiers

PMID39233852
PMCPMC11372813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.