Observational studyDevelopmental medicine and child neurology2025
Major structural congenital anomalies and causal pathways in people with cerebral palsy.
Observational study in Developmental medicine and child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The cerebral palsy directed acyclic graph: A structural causal model of aetiology.Developmental medicine and child neurology · 2026Article
- The Impact of 40 Years of Data Collection: The Victoria Cerebral Palsy Register.Children (Basel, Switzerland) · 2026Article
- Causal pathways of cerebral palsy in individuals with congenital anomalies: A cardiologist's perspective.Developmental medicine and child neurology · 2025Article
- Major structural congenital anomalies and causal pathways in people with cerebral palsy.Developmental medicine and child neurology · 2025Observational
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Authors and funding
5 authors.
Funding
Abstract
aimTo determine the proportion of persons with cerebral palsy (CP) with major congenital anomalies, factors associated with the presence of anomalies, body systems involved, potential contribution to CP aetiology, and causal pathway subgroups implicated.
methodThis population-based, observational study involved a cohort of 2238 persons born in one Australian state between 1999 and 2017. Major congenital anomalies were classified as affecting cerebral, cardiac, or other body systems, with further categorization as single or multisystem. We determined the potential for anomalies to contribute to the development of CP across causal pathway subgroups that were broadly categorized as developmental or involving destructive brain insults.
resultsOf persons with CP, 23% had major congenital anomalies and 17% of the cohort had anomalies that potentially contributed to the development of CP. Consistent with higher odds of parental consanguinity, maternal grand multiparity, and dysmorphic features in the group with anomalies, 82% of pathogenic anomalies, present in 14% of the cohort, were cerebral and involved developmental causal pathways. Only 3% (predominantly severe cardiac anomalies) were related to destructive brain insults.
interpretationThe study provides context for the impact on rates of CP of preventive measures or other changes in incidence or management of congenital anomalies.
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