Evidence map›Paper›PMID 39233557›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Tumor-Homing Phage Nanofibers for Nanozyme-Enhanced Targeted Breast Cancer Therapy.

Tao Yang, Qinglei Zhang, Yao Miao, Yang Lyu, Yajing Xu, Mingying Yang, Chuanbin Mao

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Emerging Nanozyme Strategies for Precision Breast Cancer Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Article
  12. Targeting breast cancer: the promise of phage-based nanomedicines.Breast cancer research and treatment · 2025
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tao YangSchool of Materials Science & Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
Qinglei ZhangInstitute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
Yao MiaoSchool of Materials Science & Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
Yang LyuDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, P. R. China.
Yajing XuDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, P. R. China.
Mingying YangInstitute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
Chuanbin MaoDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, P. R. China.ORCID 0000-0002-8142-3659

Funding

General Research Fund of Hong Kong 14208723
6 · The paper itself

Abstract

Photodynamic therapy (PDT) eliminates cancer cells by converting endogenous oxygen into reactive oxygen species (ROS). However, its efficacy is significantly hindered by hypoxia in solid tumors. Hence, to engineer filamentous fd phage, a human-friendly bacteria-specific virus is proposed, into a nanozyme-nucleating photosensitizer-loaded tumor-homing nanofiber for enhanced production of ROS in a hypoxic tumor. Specifically, Pt-binding and tumor-homing peptides are genetically displayed on the sidewall and tip of the fd phage, respectively. The Pt-binding peptides induced nucleation and orientation of Pt nanozymes (PtNEs) on the sidewall of the phage. The resultant PtNE-coated tumor-homing phage exhibits significantly enhanced sustained catalytic conversion of hydrogen peroxide in hypoxic tumors into O

Indexed as

Breast NeoplasmsNanofibersPhotosensitizing AgentsAnimalsCell Line, TumorFemaleHumansHydrogen PeroxideMicePhotochemotherapyPlatinumReactive Oxygen SpeciesHydrogen PeroxidePhotosensitizing AgentsPlatinumReactive Oxygen Specieshydrogen peroxide decompositionhypoxic tumorphage nanofibersphotodynamic therapyplatinum nanozyme

Identifiers

PMID39233557
PMCPMC11733710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.