Evidence map›Paper›PMID 39233507›Full record

ArticleMagnetic resonance in medicine2025

Joint learning of nonlinear representation and projection for fast constrained MRSI reconstruction.

Yahang Li, Loreen Ruhm, Zepeng Wang, Ruiyang Zhao, Aaron Anderson, Paul Arnold, Graham Huesmann, Anke Henning, Fan Lam

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yahang LiDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0001-6206-8228
Loreen RuhmAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Zepeng WangDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0001-8877-5270
Ruiyang ZhaoBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Aaron AndersonBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0003-0440-3416
Paul ArnoldBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Graham HuesmannBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Anke HenningAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Fan LamDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-4124-0663

Funding

Towards In Vivo Imaging of Tissue MetabolomicsR35GM142969 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Fan Lam · 2021 to 2026
$2.4M
A New J-Resolved MRSI Framework for Whole-Brain Simultaneous Metabolite and Neurotransmitter MappingR21EB029076 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LAM, FAN · 2020 to 2020
$566k
Cancer Prevention and Research Institute of Texas RR180056European Research Council Starting Grant 679927National Science Foundation, Division of Chemical, Bioengineering, Environmental, and Transport Systems CAREER1944249NIBIB NIH HHS NIH-R21EB029076NIBIB NIH HHS R21 EB029076NIGMS NIH HHS NIH-R35GM142969NIGMS NIH HHS R35 GM142969
6 · The paper itself

Abstract

purposeTo develop and evaluate a novel method for computationally efficient reconstruction from noisy MR spectroscopic imaging (MRSI) data.

methodsThe proposed method features (a) a novel strategy that jointly learns a nonlinear low-dimensional representation of high-dimensional spectroscopic signals and a neural-network-based projector to recover the low-dimensional embeddings from noisy/limited data; (b) a formulation that integrates the forward encoding model, a regularizer exploiting the learned representation, and a complementary spatial constraint; and (c) a highly efficient algorithm enabled by the learned projector within an alternating direction method of multipliers (ADMM) framework, circumventing the computationally expensive network inversion subproblem.

resultsThe proposed method has been evaluated using simulations as well as in vivo

conclusionA novel method was developed for fast, high-SNR spatiospectral reconstruction from noisy MRSI data. We expect our method to be useful for enhancing the quality of MRSI or other high-dimensional spatiospectral imaging data.

Indexed as

AlgorithmsBrainImage Processing, Computer-AssistedMagnetic Resonance ImagingComputer SimulationHumansMagnetic Resonance SpectroscopyNeural Networks, ComputerSignal-To-Noise Ratioconstrained reconstructiondenoisingMR spectroscopic imagingnetwork‐based projectionneural networkrepresentation learning

Identifiers

PMID39233507
PMCPMC11604835

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.