ArticlePlant communications2024
Lr34/Yr18/Sr57/Pm38 confers broad-spectrum resistance to fungal diseases via sinapyl alcohol transport for cell wall lignification in wheat.
Article in Plant communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Apoplast Engineering Unveiled: Multi-Target Strategies to Disarm Pathogens and Elevate Global Food Security.Plant, cell & environment · 2026Review
- Identification of candidate gene for the wheat powdery mildew resistance gene Pm40 by bulked segregant analysis coupled with whole-genome sequencing (BSA-seq).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Genetic Background-Dependent Expression ofInternational journal of molecular sciences · 2026Article
- From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Genetic analysis and mapping of adult plant stripe rust resistance loci in CIMMYT wheat 'Kijil' under Mexican and Chinese field environments.PLoS genetics · 2026Article
- Comparative analysis of ABC, LTP, and WAK families in non-specific immunity of wheat and sunflower.Scientific reports · 2026Article
- Identification of stripe rust adult plant resistance genes in the hard winter wheat cultivar Baker's Ann.The plant genome · 2026Article
- Integrative metabolomics and molecular networking reveal the progressive metabolic continuum of resin formation inFrontiers in molecular biosciences · 2026Article
- Integrative evolutionary and structural modeling of leaf rust resistance genes in wheat (Frontiers in plant science · 2026Article
- Current Status and Future Direction of the High-Temperature Resistance in Wheat to Control Stripe Rust.Molecular plant pathology · 2025Review
- Silica nanoparticles suppress fungal pathogenic allies to alleviate Astragalus root rot.Microbiome · 2025Article
- Foliar disease resistance phenomics of fungal pathogens: image-based approaches for mapping quantitative resistance in cereal germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Suppressing wheat sucrose phosphate synthase 1-B protects wheat against stripe rust.Journal of advanced research · 2025Article
- Unveiling yellow rust resistance in the near-Himalayan region: insights from a nested association mapping study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Characterizing the Genetic Basis of Winter Wheat Rust Resistance in Southern Kazakhstan.Plants (Basel, Switzerland) · 2025Article
- Association analysis of response to take-all disease with agronomic traits and molecular markers and selection ideal genotypes in bread wheat (Molecular breeding : new strategies in plant improvement · 2025Article
- Fatty Acid ABCG TransporterPlants (Basel, Switzerland) · 2025Article
- Unraveling Effects of miRNAs Associated with APR Leaf Rust Resistance Genes in Hybrid Forms of Common Wheat (International journal of molecular sciences · 2025Article
- Transcriptome andFrontiers in plant science · 2025Article
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Authors and funding
17 authors.
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Abstract
The widely recognized pleiotropic adult plant resistance gene Lr34 encodes an ATP-binding cassette transporter and plays an important role in breeding wheat for enhanced resistance to multiple fungal diseases. Despite its significance, the mechanisms underlying Lr34-mediated pathogen defense remain largely unknown. Our study demonstrates that wheat lines carrying the Lr34res allele exhibit thicker cell walls and enhanced resistance to fungal penetration compared to those without Lr34res. Transcriptome and metabolite profiling revealed that the lignin biosynthetic pathway is suppressed in lr34 mutants, indicating a disruption in cell wall lignification. Additionally, we discovered that lr34 mutant lines are hypersensitive to sinapyl alcohol, a major monolignol crucial for cell wall lignification. Yeast accumulation and efflux assays confirmed that the LR34 protein functions as a sinapyl alcohol transporter. Both genetic and virus-induced gene silencing experiments demonstrated that the disease resistance conferred by Lr34 can be enhanced by incorporating the TaCOMT-3B gene, which is responsible for the biosynthesis of sinapyl alcohol. Collectively, our findings provide novel insights into the role of Lr34 in disease resistance through mediating sinapyl alcohol transport and cell wall deposition, and highlight the synergistic effect of TaCOMT-3B and Lr34 against multiple fungal pathogens by mediating cell wall lignification in adult wheat plants.
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