Evidence map›Paper›PMID 39233365›Full record

ArticleJournal of neurochemistry2025

Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal.

Brandon K Richards, Sarah S Ch'ng, Ariel B Simon, Terence Y Pang, Jee Hyun Kim, Andrew J Lawrence, Christina J Perry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brandon K RichardsThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID 0000-0002-4699-7585
Sarah S Ch'ngThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID 0000-0003-4927-796X
Ariel B SimonThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Terence Y PangThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Jee Hyun KimThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Andrew J LawrenceThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.ORCID 0000-0001-6836-727X
Christina J PerryThe Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

Funding

Australian Research Council DP210102672International Society for NeurochemistryMacquarie University Research Excellence Scholarship 20224425National Health and Medical Research Council 1079893
6 · The paper itself

Abstract

Fear-related psychopathologies, such as post-traumatic stress disorder, are linked to dysfunction in neural circuits that govern fear memory and arousal. The lateral hypothalamus (LH) and zona incerta (ZI) regulate fear, but our understanding of the precise neural circuits and cell types involved remains limited. Here, we examined the role of relaxin family peptide receptor 3 (RXFP3) expressing cells in the LH/ZI in conditioned fear expression and general arousal in male RXFP3-Cre mice. We found that LH/ZI RXFP3+ (LH/ZI

Indexed as

ArousalFearHypothalamic Area, LateralReceptors, G-Protein-CoupledZona IncertaAnimalsConditioning, ClassicalMaleMiceMice, Inbred C57BLMice, TransgenicReceptors, G-Protein-Coupledarousaldefensive responsefear conditioninghypothalamusRXFP3zona incerta

Identifiers

PMID39233365
PMCPMC11658188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.