Evidence map›Paper›PMID 39232744›Full record

Observational studyEnvironmental health : a global access science source2024

Greater exposure to PM

Sara B A Mokhtar, Jessica Viljoen, Carla J H van der Kallen, Tos T J M Berendschot, Pieter C Dagnelie, Jeroen D Albers, Jens Soeterboek, Fabio Scarpa, Alessia Colonna, Frank C T van der Heide and 10 more

Abstract readObservational Study
In one paragraph

Observational study in Environmental health : a global access science source, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Greater exposure to PMScientific reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sara B A MokhtarDepartment of Internal Medicine, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands. s.mokhtar@maastrichtuniversity.nl.
Jessica ViljoenDepartment of Internal Medicine, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.
Carla J H van der KallenDepartment of Internal Medicine, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.
Tos T J M BerendschotSchool of Mental Health and Neuroscience, University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Pieter C DagnelieDepartment of Internal Medicine, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.
Jeroen D AlbersDepartment of Social Medicine, Maastricht University, Maastricht, The Netherlands.
Jens SoeterboekAlzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands.
Fabio ScarpaDepartment of Information Engineering, University of Padova, Padua, Italy.
Alessia ColonnaDepartment of Information Engineering, University of Padova, Padua, Italy.
Frank C T van der HeideUniversité de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Paris, France.
Marleen M J van GreevenbroekDepartment of Internal Medicine, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.
Hans BosmDepartment of Social Medicine, Maastricht University, Maastricht, The Netherlands.
Abraham A KroonDepartment of Internal Medicine, School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.
Rudy M M A NuijtsSchool of Mental Health and Neuroscience, University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Marlies GijsSchool of Mental Health and Neuroscience, University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Jeroen LakerveldGlobal Geo Health Data Center, University Medical Center Utrecht & Utrecht University, Utrecht, the Netherlands.
Rayaz A MalikDepartment of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Carroll A B WebersSchool of Mental Health and Neuroscience, University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Coen D A StehouwerDepartment of Chronic Diseases and Metabolism (CHROMETA), KU Louvain, Louvain, Belgium.
Annemarie KosterDepartment of Social Medicine, Maastricht University, Maastricht, The Netherlands.

Funding

OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs 31O.041
6 · The paper itself

Abstract

backgroundEpidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy.

methodsWe used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM

resultsAfter adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM

conclusionsOur population-based study demonstrated that exposure to higher levels of PM

Indexed as

Air PollutantsCorneaEnvironmental ExposureParticulate MatterAdultAgedCross-Sectional StudiesFemaleHumansMaleMicroscopy, ConfocalMiddle AgedNetherlandsAir PollutantsParticulate MatterAir pollutionCorneal nervesElemental carbonNeurodegenerationNO2Particulate matter

Identifiers

PMID39232744
PMCPMC11375839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.