Evidence map›Paper›PMID 39232173›Full record

ArticleNature2024

Diverse viral cas genes antagonize CRISPR immunity.

Mark A Katz, Edith M Sawyer, Luke Oriolt, Albina Kozlova, Madison C Williams, Shally R Margolis, Matthew Johnson, Joseph Bondy-Denomy, Alexander J Meeske

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. High-sensitivity, protein-independent detection of dsDNA sequences.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Pathogen-Phage Geomapping to Overcome Resistance.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark A Katz *Department of Microbiology, University of Washington, Seattle, WA, USA.
Edith M Sawyer *Department of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0009-0007-6560-6627
Luke OrioltDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Albina KozlovaDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Madison C WilliamsDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8340-4443
Shally R MargolisDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Matthew JohnsonDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Joseph Bondy-DenomyDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4909-9481
Alexander J MeeskeDepartment of Microbiology, University of Washington, Seattle, WA, USA. meeske@uw.edu.ORCID 0000-0003-3878-531X

Funding

Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
CRISPR-Cas13 immunity in Listeria seeligeriR35GM142460 · NIGMS · UNIVERSITY OF WASHINGTON · PI Alexander Jacob Meeske · 2021 to 2026
$2.7M
Uncovering the mechanism and role of a widespread anti-CRISPR-Cas9 proteinR01GM127489 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2018 to 2022
$1.7M
Azure Sapphire BioimagerS10OD026741 · OD · UNIVERSITY OF WASHINGTON · PI SMITH, JASON G · 2019 to 2019
$76k
NIGMS NIH HHS R01 GM127489NIGMS NIH HHS R35 GM142460NIGMS NIH HHS T32 GM136534NIH HHS S10 OD026741
6 · The paper itself

Abstract

Prokaryotic CRISPR-Cas immunity is subverted by anti-CRISPRs (Acrs), which inhibit Cas protein activities when expressed during the phage lytic cycle or from resident prophages or plasmids

Indexed as

BacteriophagesCRISPR-Associated ProteinsCRISPR-Cas SystemsEvolution, MolecularGenes, ViralListeriaClustered Regularly Interspaced Short Palindromic RepeatsGene EditingGenome, BacterialGenome, ViralMultigene FamilyCRISPR-Associated Proteins

Identifiers

PMID39232173
PMCPMC11991930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.