Evidence map›Paper›PMID 39232164›Full record

ArticleNature2024

A pathology foundation model for cancer diagnosis and prognosis prediction.

Xiyue Wang, Junhan Zhao, Eliana Marostica, Wei Yuan, Jietian Jin, Jiayu Zhang, Ruijiang Li, Hongping Tang, Kanran Wang, Yu Li and 19 more

Abstract readValidation Study
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed.

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204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Xiyue Wang *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3597-9090
Junhan Zhao *Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0316-8365
Eliana MarosticaDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Wei YuanCollege of Biomedical Engineering, Sichuan University, Chengdu, China.
Jietian JinDepartment of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jiayu ZhangCollege of Biomedical Engineering, Sichuan University, Chengdu, China.
Ruijiang LiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0232-5998
Hongping TangDepartment of Pathology, Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, China.
Kanran WangDepartment of Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China.
Yu LiDepartment of Pathology, Chongqing University Cancer Hospital, Chongqing, China.
Fang WangDepartment of Pathology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Yulong PengDepartment of Pathology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Junyou ZhuDepartment of Burn, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jing ZhangCollege of Biomedical Engineering, Sichuan University, Chengdu, China.ORCID 0000-0003-2663-053X
Christopher R JacksonDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Jun ZhangTencent AI Lab, Shenzhen, China.
Deborah DillonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Nancy U LinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-2263-5413
Lynette ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Thomas DenizeDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
David MeredithDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Keith L LigonDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7733-600X
Sabina SignorettiDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-5000-9105
Shuji OginoDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-3909-2323
Jeffrey A GoldenDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
MacLean P NasrallahDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4861-0898
Xiao HanTencent AI Lab, Shenzhen, China.ORCID 0000-0002-5151-6547
Sen YangDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. sen.yang.scu@gmail.com.ORCID 0000-0002-0639-4122
Kun-Hsing YuDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Kun-Hsing_Yu@hms.harvard.edu.ORCID 0000-0001-9892-8218

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WENDY Beth LONDON · 2013 to 2026
$33.5M
Robust, Generalizable, and Fair Machine Learning Models for BiomedicineR35GM142879 · NIGMS · HARVARD MEDICAL SCHOOL · PI YU, KUN-HSING · 2021 to 2025
$2.4M
Mitigating Hematologic Adverse Events in Patients with Myeloid Malignancies: A Novel Causal Artificial Intelligence ApproachR01HL174679 · NHLBI · HARVARD MEDICAL SCHOOL · PI Kun-Hsing Yu · 2024 to 2026
$2.3M
NCI NIH HHS P50 CA165962NHLBI NIH HHS R01 HL174679NIGMS NIH HHS R35 GM142879
6 · The paper itself

Abstract

Histopathology image evaluation is indispensable for cancer diagnoses and subtype classification. Standard artificial intelligence methods for histopathology image analyses have focused on optimizing specialized models for each diagnostic task

Indexed as

HistocytochemistryNeoplasmsPathology, ClinicalPattern Recognition, AutomatedDatasets as TopicDeep LearningFemaleHumansMalePrognosisReproducibility of ResultsSensitivity and SpecificitySupervised Machine Learning

Identifiers

PMID39232164
PMCPMC12186853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.