ArticleNature2024
A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Molecular Mechanisms of Age-Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics.Aging cell · 2026Article
- Review
- Sensory neurons shape γδ T cell effector programs to control Psoriasiform Inflammation.bioRxiv : the preprint server for biology · 2026Article
- The JAK-STAT pathway in allergic diseases: from pathogenesis to targeted therapy.Biomarker research · 2026Review
- Review
- γδ T Cell-Mediated Neuroimmune Interactions in Skin Inflammation and Allergy.Clinical reviews in allergy & immunology · 2026Review
- Identifying microbial protease allergens through protein language model-guided homology.Cell systems · 2026Article
- The neuro-immune insights of itch: peripheral mechanisms and central glial contributions.Cellular & molecular biology letters · 2026Review
- Calcitonin gene-related peptide as a neuroimmune amplifier in allergic rhinitis: from disease worsening to targeted drug intervention.Frontiers in immunology · 2026Review
- Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Connection and communication between the nervous and immune systems.Nature reviews. Immunology · 2025Review
- Central neural circuits underlying itch sensation.Nature reviews. Neuroscience · 2025Review
- ZFP612 controls neuropathic pain through epigenetic repression of Il1rl1 within the silencer-promoter loop in primary sensory neurons of male mice.Nature communications · 2025Article
- The immunology of asthma.Nature immunology · 2025Review
- Skin Resident T Cell Interactions with NPY1RbioRxiv : the preprint server for biology · 2025Article
- Mechanism-based nonopioid analgesic targets.The Journal of clinical investigation · 2025Review
- Microbiota-neuroepithelial signalling across the gut-brain axis.Nature reviews. Microbiology · 2025Review
- Neuroimmune Circuits in Allergic Diseases.Annual review of immunology · 2025Review
- Neurogenic inflammation and itch in barrier tissues.Seminars in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Cameron H FlayerCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3001-9058
Isabela J Kernin *Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Peri R Matatia *Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5389-3637
Xiangsunze ZengFM Kirby Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
David A YarmolinskyFM Kirby Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Cai HanCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Parth R NaikCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0009-0003-0385-4597
Dean R ButtaciCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Pamela A AderholdCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ryan B CamireDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Xueping ZhuCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alice J TirardCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
John T McGuireCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Neal P SmithCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1394-3158
Clive S McKimmieVirus Host Interaction Team, Skin Research Centre, University of York, York, UK.ORCID 0000-0002-7694-9509
Cameron S McAlpineCardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9832-6345
Filip K SwirskiCardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3163-9152
Clifford J WoolfFM Kirby Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6636-3897
Alexandra-Chloe VillaniCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7461-0408
Caroline L SokolCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. clsokol@mgh.harvard.edu.ORCID 0000-0003-0473-7555
Funding
Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MThe adaptive-innate immune interactome across multiple tissues in Alzheimer's diseaseR01AG082185 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VAHRAM HAROUTUNIAN, Donghoon Lee · 2023 to 2026
$9.0MResearch Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6MMacrophages in homeostasis and cardiovascular diseaseR35HL135752 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2017 to 2023
$5.4MSpinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate PainR01AT011447 · NCCIH · HARVARD MEDICAL SCHOOL · PI DRUGOWITSCH, JAN, GINTY, DAVID D · 2020 to 2024
$5.3MNeuroimmune Control of Allergic ImmunityR01AI151163 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SOKOL, CAROLINE LAUREN · 2021 to 2025
$3.2MDeciphering the Achilles Heel of Cancer ImmunotherapyDP2CA247831 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VILLANI, ALEXANDRA-CHLOE · 2019 to 2019
$2.5MInfluence of sleep on the hematopoietic niche and atherosclerosis during agingR01HL158534 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2025
$2.1MInfluence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseK99HL151750 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MCALPINE, CAMERON STUART · 2020 to 2020
$171kNCCIH NIH HHS R01 AT011447NCI NIH HHS DP2 CA247831NHLBI NIH HHS K99 HL151750NHLBI NIH HHS R01 HL158534NHLBI NIH HHS R35 HL135752NHLBI NIH HHS T32 HL116275NIAID NIH HHS R01 AI151163NIA NIH HHS R01 AG082185NICHD NIH HHS P50 HD105351NINDS NIH HHS R35 NS105076
Abstract
In naive individuals, sensory neurons directly detect and respond to allergens, leading to both the sensation of itch and the activation of local innate immune cells, which initiate the allergic immune response
Indexed as
HypersensitivityInterleukin-3Intraepithelial LymphocytesPruritusReceptors, Antigen, T-Cell, gamma-deltaSensory Receptor CellsAllergensAnimalsDisease SusceptibilityEpidermisFemaleHumansInterleukin-3 Receptor alpha SubunitJanus Kinase 2MaleMiceAllergensIL3 protein, humanIl3 protein, mouseIL3RA protein, humanInterleukin-3Interleukin-3 Receptor alpha SubunitJAK2 protein, humanJanus Kinase 2Receptors, Antigen, T-Cell, gamma-deltaSTAT5 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.