Evidence map›Paper›PMID 39232148›Full record

ArticleNature2024

Mechanisms that clear mutations drive field cancerization in mammary tissue.

Marta Ciwinska, Hendrik A Messal, Hristina R Hristova, Catrin Lutz, Laura Bornes, Theofilos Chalkiadakis, Rolf Harkes, Nathalia S M Langedijk, Stefan J Hutten, Renée X Menezes and 6 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Advanced Microscopy Techniques.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marta Ciwinska *VIB-KULeuven Centre for Cancer Biology, Department of Oncology, Leuven, Belgium.
Hendrik A Messal *Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0003-2259-0286
Hristina R Hristova *Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Catrin LutzDivision of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Laura BornesDivision of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0001-9721-1223
Theofilos ChalkiadakisCentre for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.
Rolf HarkesBioimaging Facility, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Nathalia S M LangedijkDivision of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0002-1069-2704
Stefan J HuttenDivision of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0001-5395-8392
Renée X MenezesBiostatistics Centre and Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Jos JonkersDivision of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID 0000-0002-9264-9792
Stefan PrekovicCentre for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.
Grand Challenge PRECISION consortium
Benjamin D SimonsGurdon Institute, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.ORCID 0000-0002-3875-7071
Colinda L G J ScheeleVIB-KULeuven Centre for Cancer Biology, Department of Oncology, Leuven, Belgium. colinda.scheele@kuleuven.be.ORCID 0000-0001-8999-5451
Jacco van RheenenDivision of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands. j.v.rheenen@nki.nl.ORCID 0000-0001-8175-1647

Funding

Medical Research Council MC_PC_17230Wellcome Trust
6 · The paper itself

Abstract

Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form tumours

Indexed as

Cell Transformation, NeoplasticMammary Glands, AnimalMutationAnimalsBRCA1 ProteinCell LineageCell Self RenewalClone CellsEstrous CycleFemaleMiceStem CellsTumor Suppressor Protein p53BRCA1 ProteinBrca1 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID39232148
PMCPMC11374684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.