Evidence map›Paper›PMID 39232115›Full record

ArticleCommunications biology2024

Extracting regulatory active chromatin footprint from cell-free DNA.

Kevin Lai, Katharine Dilger, Rachael Cunningham, Kathy T Lam, Rhea Boquiren, Khiet Truong, Maggie C Louie, Richard Rava, Diana Abdueva

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin LaiAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Katharine DilgerAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Rachael CunninghamAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Kathy T LamAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Rhea BoquirenAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Khiet TruongAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Maggie C LouieAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Richard RavaAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA.
Diana AbduevaAQTUAL Inc., 31145 San Antonio Street, Hayward, CA, 94544, USA. diana.abdueva@aqtual.com.ORCID 0009-0000-4159-0084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-free DNA (cfDNA) has emerged as a pivotal player in precision medicine, revolutionizing the diagnostic and therapeutic landscape. While its clinical applications have significantly increased in recent years, current cfDNA assays have limited ability to identify the active transcriptional programs that govern complex disease phenotypes and capture the heterogeneity of the disease. To address these limitations, we have developed a non-invasive platform to enrich and examine the active chromatin fragments (cfDNA

Indexed as

Cell-Free Nucleic AcidsChromatinEpigenesis, GeneticEpigenomicsHumansNucleosomesPromoter Regions, GeneticRNA Polymerase IICell-Free Nucleic AcidsChromatinNucleosomesRNA Polymerase II

Identifiers

PMID39232115
PMCPMC11375110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.