Evidence map›Paper›PMID 39232002›Full record

ArticleNature communications2024

Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.

Amirthagowri Ambalavanan, Le Chang, Jihoon Choi, Yang Zhang, Sara A Stickley, Zhi Y Fang, Kozeta Miliku, Bianca Robertson, Chloe Yonemitsu, Stuart E Turvey and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Secretor status-dependent modulation ofFrontiers in nutrition · 2026
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  10. Observational
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  12. Environmental and Maternal Imprints on Infant Gut Metabolic Programming.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. [Effect of interleukinZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Amirthagowri AmbalavananDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Le ChangDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID 0000-0002-0966-7923
Jihoon ChoiDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Yang ZhangSchool of Computing, Queen's University, Kingston, ON, Canada.
Sara A StickleyDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.ORCID 0009-0003-7958-4650
Zhi Y FangDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Kozeta MilikuDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Bianca RobertsonDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA.
Chloe YonemitsuDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA.
Stuart E TurveyDepartment of Pediatrics, Division of Allergy and Immunology, University of British Columbia, Vancouver, BC, Canada.
Piushkumar J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Elinor SimonsDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Theo J MoraesDepartment of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Sonia S AnandChanchlani Research Centre, Dept. of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-3692-7441
Guillaume ParéPathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-6795-4760
Janet E WilliamsDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0002-9769-1789
Brenda M MurdochDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.ORCID 0000-0001-8675-3473
Gloria E OtooDepartment of Nutrition & Food Science, University of Ghana, Accra, Ghana.
Samwel MbuguaDepartment of Human Nutrition, Egerton University, Nakuru, Kenya.
Elizabeth W Kamau-MbuthiaDepartment of Human Nutrition, Egerton University, Nakuru, Kenya.
Egidioh W KamundiaDepartment of Human Nutrition, Egerton University, Nakuru, Kenya.
Debela K GindolaDepartment of Anthropology, Hawassa University, Hawassa, Ethiopia.
Juan M RodriguezDepartment of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
Rossina G ParejaNutrition Research Institute, Lima, Peru.
Daniel W SellenDepartment of Anthropology, University of Toronto, Toronto, ON, Canada.
Sophie E MooreDepartment of Women and Children's Health, King's College London, London, UK.
Andrew M PrenticeThe Medical Research Council Unit, The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, Gambia.
James A FosterDepartment of Biological Sciences, University of Idaho, Moscow, ID, USA.
Linda J KvistFaculty of Medicine, Lund University, Lund, Sweden.
Holly L NeibergsDepartment of Animal Sciences, Washington State University, Pullman, WA, USA.
Mark A McGuireDepartment of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, USA.
Michelle K McGuireMargaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, USA.ORCID 0000-0001-8214-2229
Courtney L MeehanDepartment of Anthropology, Washington State University, Pullman, WA, USA.
Malcolm R SearsDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Padmaja SubbaraoDepartment of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-0394-1933
Meghan B AzadDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada. meghan.azad@umanitoba.ca.ORCID 0000-0002-5942-4444
Lars BodeDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California San Diego, La Jolla, CA, USA. lbode@health.ucsd.edu.ORCID 0000-0002-9914-9571
Qingling DuanDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. qingling.duan@queensu.ca.ORCID 0000-0003-4467-7024

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MRT-168044Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-178390
6 · The paper itself

Abstract

Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e-118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6'-sialyllactose (P = 2.2e-9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P < 0.01). Thus, we report novel genetic factors associated with HMOs, some of which may protect the respiratory health of children.

Indexed as

Genome-Wide Association StudyMilk, HumanOligosaccharidesSialyltransferasesAdultBreast FeedingChildChild, PreschoolChromosomes, Human, Pair 3Cohort StudiesFemaleFucosyltransferasesGene-Environment InteractionHumansInfantLactose6'-sialyllactoseFucosyltransferasesLactoseOligosaccharidesSialyltransferases

Identifiers

PMID39232002
PMCPMC11375010

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.