Evidence map›Paper›PMID 39231957›Full record

ArticleJournal of medicinal chemistry2024

Photostable Iridium(III) Cyclometallated Complex is an Efficient Photosensitizer for Killing Multiple Cancer Cell Lines and 3D Models under Low Doses of Visible Light.

Callum Jones, Marta Martinez-Alonso, Hannah Gagg, Liam Kirby, Julia A Weinstein, Helen E Bryant

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. DNA-Binding Properties of Iridium(III) Complexes Encompassing Design, Function and Biophysical Assessments.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Callum JonesSchool of Medicine and Population Health, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, U.K.
Marta Martinez-AlonsoSchool of Medicine and Population Health, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, U.K.ORCID 0000-0002-0931-5274
Hannah GaggSchool of Medicine and Population Health, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, U.K.
Liam KirbyDepartment of Chemistry, University of Sheffield, Sheffield S3 7HF, U.K.
Julia A WeinsteinDepartment of Chemistry, University of Sheffield, Sheffield S3 7HF, U.K.
Helen E BryantSchool of Medicine and Population Health, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, U.K.ORCID 0000-0003-2720-7020

Funding

Wellcome Trust
6 · The paper itself

Abstract

Photodynamic therapy delivers more targeted cell killing than classical chemotherapy. It uses light-absorbing compounds, photosensitizers (PSs), to generate lethal reactive oxygen species (ROS) at sites of localized irradiation. Transition metal complexes are attractive PSs due to their photostability, visible-light absorption, and high ROS yields. Here, we introduce a low-molecular weight, photostable iridium complex, [Ir(thpy)

Indexed as

Coordination ComplexesIridiumLightPhotochemotherapyPhotosensitizing AgentsAntineoplastic AgentsCell Line, TumorHumansReactive Oxygen SpeciesAntineoplastic AgentsCoordination ComplexesIridiumPhotosensitizing AgentsReactive Oxygen Species

Identifiers

PMID39231957
PMCPMC11440503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.