Evidence map›Paper›PMID 39231880›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Non-invasive diagnosis of liver fibrosis via MRI using targeted gadolinium-based nanoparticles.

Shiman Wu, Tingting Xu, Jiahao Gao, Qi Zhang, Yuxin Huang, Zonglin Liu, Xiaozhu Hao, Zhenwei Yao, Xing Hao, Pu-Yeh Wu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shiman Wu *Department of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Tingting Xu *Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Jiahao Gao *Department of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Qi ZhangDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Yuxin HuangDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Zonglin LiuDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Xiaozhu HaoDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Zhenwei YaoDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China.
Xing HaoDepartment of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.
Pu-Yeh WuGE Healthcare, Beijing, 100176, P.R. China.
Yue WuDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China. wuyue0115@foxmail.com.
Bo YinDepartment of Radiology, Huashan hospital, Fudan University, 200040, Shanghai, P. R. China. yinbo@fudan.edu.cn.
Zhongmin TangShanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai, 200072, P. R. China. zhongmintang@tongji.edu.cn.ORCID 0000-0002-1532-8004

Funding

National Natural Science Foundation of China 82271966National Natural Science Foundation of China 82272061National Overseas Young Talents Program National Overseas Young Talents ProgramNational Postdoctoral Program for Innovative Talents BX20230090the Fundamental Research Funds for the Central Universities the Fundamental Research Funds for the Central Universities
6 · The paper itself

Abstract

introductionAccurate diagnosis of liver fibrosis is crucial for preventing cirrhosis and liver tumors. Liver fibrosis is driven by activated hepatic stellate cells (HSCs) with elevated CD44 expression. We developed hyaluronic acid (HA)-coated gadolinium-based nanoprobes to specifically target CD44 for diagnosing liver fibrosis using T1-weighted magnetic resonance imaging (MRI). MATERIALS AND

methodsNaGdF

resultsNaGdF

conclusionsNaGdF

Indexed as

GadoliniumLiver CirrhosisMagnetic Resonance ImagingMice, Inbred C57BLAnimalsCell LineContrast MediaHepatic Stellate CellsHyaluronan ReceptorsHyaluronic AcidMaleMiceNanoparticlesPolyethylene GlycolsContrast MediaGadoliniumHyaluronan ReceptorsHyaluronic AcidPolyethylene GlycolsGadoliniumHyaluronic acidLiver fibrosisMRINanoprobes

Identifiers

PMID39231880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.