Evidence map›Paper›PMID 39231863›Full record

ArticleJournal of thrombosis and thrombolysis2024

Heparin-like effect of a dual antiplatelet and anticoagulant (APAC) agent on red blood cell deformability and aggregation in an experimental model.

Adam Attila Matrai, Adam Varga, Barbara Bedocs-Barath, Erzsebet Vanyolos, Rita Orban-Kalmandi, Linda Loczi, Zsuzsa Bagoly, Annukka Jouppila, Riitta Lassila, Norbert Nemeth and 1 more

Abstract read
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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adam Attila MatraiDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, Debrecen, H-4032, Hungary.
Adam VargaDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, Debrecen, H-4032, Hungary.
Barbara Bedocs-BarathDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, Debrecen, H-4032, Hungary.
Erzsebet VanyolosDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, Debrecen, H-4032, Hungary.
Rita Orban-KalmandiDivision of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, and Hungarian Research Network (HUN-REN-DE) Cerebrovascular Research Group, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.
Linda LocziDivision of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, and Hungarian Research Network (HUN-REN-DE) Cerebrovascular Research Group, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.
Zsuzsa BagolyDivision of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, and Hungarian Research Network (HUN-REN-DE) Cerebrovascular Research Group, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.
Annukka JouppilaHelsinki University Hospital Clinical Research Institute, Tukholmankatu 8, Helsinki, FI-00290, Finland.
Riitta LassilaCoagulation Disorders Unit, Departments of Hematology and Comprehensive Cancer Center and Research Program Unit in Systems Oncology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, Helsinki, FI- 00290, Finland.
Norbert NemethDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, Debrecen, H-4032, Hungary.
Adam DeakDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, Debrecen, H-4032, Hungary. deak.adam@med.unideb.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatments with different antithrombotic agents can affect micro-rheological variables, such as red blood cell (RBC) deformability and aggregation. Since the effect of dual antiplatelet and anticoagulant (APAC) treatment on micro-rheology is unknown, we aimed to investigate the effect of different intravenous doses of APAC on hematological and micro-rheological variables in a porcine model. Two groups were formed (APAC group, Control group), and blood was collected from the animals at preset intervals. Hematological variables, RBC deformability, and aggregation were measured. We observed an improvement in the RBC deformability measured at a low shear stress range (< 3 Pa). However, after both doses, a decrease in the maximal elongation index of RBC values occurred in the APAC group. RBC aggregation increased after APAC bolus dose, while it gradually and dose-dependently decreased. Supposedly, the improvement in RBC deformability that was observed at a lower shear rate could facilitate aggregation. Administration of APAC and unfractionated heparin (UFH) caused comparable changes in hematological and hemorheological variables. Signs of thrombosis or bleeding did not occur. APAC and UFH had comparable micro-rheological effects.

Indexed as

AnticoagulantsErythrocyte AggregationErythrocyte DeformabilityHeparinPlatelet Aggregation InhibitorsAnimalsSwineAnticoagulantsHeparinPlatelet Aggregation InhibitorsAnticoagulantAntiplateletHemorheologyRed blood cell aggregationRed blood cell deformability

Identifiers

PMID39231863
PMCPMC11645326

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.