Impact of Drug Elution on Infectious Outcomes after Ductal Stenting in Newborns.

Keyhan Sayadpour Zanjani, Aliakbar Zeinaloo, Elaheh Malakan Rad, Sara Norouzi, Kayvan Mirnia, Mojtaba Gorji

Abstract readObservational Study

In one paragraph

Observational study in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Keyhan Sayadpour ZanjaniPediatric Cardiology Department, Children's Medical Center (affiliated to Tehran University of Medical Sciences), No. 62, Dr Gharib Street, Tehran, Iran.

Aliakbar ZeinalooPediatric Cardiology Department, Children's Medical Center (affiliated to Tehran University of Medical Sciences), No. 62, Dr Gharib Street, Tehran, Iran.

Elaheh Malakan RadPediatric Cardiology Department, Children's Medical Center (affiliated to Tehran University of Medical Sciences), No. 62, Dr Gharib Street, Tehran, Iran.

Sara NorouziPediatric Cardiology Department, Children's Medical Center (affiliated to Tehran University of Medical Sciences), No. 62, Dr Gharib Street, Tehran, Iran.

Kayvan MirniaNeonatology Department, Children's Medical Center (affiliated to Tehran University of Medical Sciences), No. 62, Dr Gharib Street, Tehran, Iran. kayvanmirnia@yahoo.com.

Mojtaba GorjiPediatric Cardiology Department, Children's Medical Center (affiliated to Tehran University of Medical Sciences), No. 62, Dr Gharib Street, Tehran, Iran. dr.gorji.ped@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ductal stenting (DS) is an interesting palliation for neonates with duct-dependent pulmonary circulation. With the introduction of drug-eluting stents (DES), which have a lower rate of restenosis and longer patency, these stents have replaced bare metal stents (BMS) in the global market. DES release Rapamycin group drugs, which have anti-proliferative and immunosuppressive effects. While the released drug amount is negligible in adult patients, it can lead to high blood levels in neonates, potentially increasing their risk of infections. We conducted a retrospective observational study on infants (under 2 months of age) with duct-dependent pulmonary circulation who underwent successful DS procedures between September 2013 and September 2023. Infants who received at least one DES were categorized into the DES group, while those receiving only BMS were categorized into the BMS group. We compared the prevalence of sepsis (both clinical and proven) and mortality between the two groups. We identified 53 infants (58.4% males), comprising 30 (56.6%) in the DES group and 23 (43.4%) in the BMS group. In the DES group, there were 11 cases (36.7%) of sepsis, including 8 clinical and 3 culture-positive cases. In contrast, the BMS group had 4 cases (13%) of sepsis, all of which were clinical (p = 0.053). Three patients (5.6%) died due to sepsis: two from the DES group and one from the BMS group. Six patients were suspected of having immunodeficiency (22q11.2 deletion or asplenia), with three in each group. Among these, only one patient in the DES group developed clinical sepsis. Our findings indicate that drug elution did not significantly increase the risk of infection following DS in newborns.

Indexed as

Drug-Eluting StentsDuctus Arteriosus, PatentSepsisStentsFemaleHumansImmunosuppressive AgentsInfant, NewbornMaleRetrospective StudiesSirolimusImmunosuppressive AgentsSirolimusBare metal stentClinical sepsisCoronary stentsDuct-dependent pulmonary circulationProven sepsis

Identifiers

PMID39231824

DOI10.1007/s00246-024-03625-3

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.