Evidence map›Paper›PMID 39231785›Full record

ArticleJournal of veterinary science2024

Alzheimer disease-like neuropathologic changes in a geriatric baboon (

William T Harrison, J Mark Cline, David L Caudell, Hillary F Huber, Carol A Shively, Thomas C Register, Suzanne Craft, Jason D Struthers

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William T HarrisonDeparmtent of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. wharriso@wakehealth.edu.ORCID https://orcid.org/0000-0002-0657-7164
J Mark ClineDepartment of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.ORCID https://orcid.org/0000-0003-4844-1238
David L CaudellDepartment of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.ORCID https://orcid.org/0000-0002-0530-2150
Hillary F HuberDepartment of Population Health, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID https://orcid.org/0000-0001-9734-427X
Carol A ShivelyDepartment of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.ORCID https://orcid.org/0000-0002-1536-2288
Thomas C RegisterDepartment of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.ORCID https://orcid.org/0000-0002-4078-0166
Suzanne CraftDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.ORCID https://orcid.org/0000-0003-0591-8657
Jason D StruthersDepartment of Pathology & Population Medicine, Animal Health Institute, Midwestern University, Glendale, AZ 85308, USA.ORCID https://orcid.org/0000-0003-2456-636X

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
The Wake Forest Nonhuman Primate Radiation Survivor CohortU01AI150578 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2020 to 2026
$23.7M
Womb to Tomb: Developmental Programming and Aging Interactions in PrimatesU19AG057758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CLARKE, GEOFFREY DAVID, COX, LAURA A · 2018 to 2024
$13.2M
NIAID NIH HHS U01 AI150578NIA NIH HHS P30 AG072947NIA NIH HHS U19 AG057758NIH HHS P51 OD011133Wake Forest Alzheimer's Disease Center P30 AG0720437
6 · The paper itself

Abstract

importanceAlzheimer's disease (AD) is the most common cause of dementia in the elderly with the incidence rising exponentially after the age of 65 years. Unfortunately, effective treatments are extremely limited and definite diagnosis can only be made at autopsy. This is in part due to our limited understanding of the complex pathophysiology, including the various genetic, environmental, and metabolic contributing factors. In an effort to better understand this complex disease, researchers have employed nonhuman primates as translational models. CASE PRESENTATION: This report aims to describe the AD-like neuropathology in the brain of a 37-year-old female baboon ( CONCLUSIONS AND RELEVANCE: Our results suggest that more detailed, prospective, longitudinal studies are warranted utilizing this particular species to see if they represent a viable model for human brain aging.

Indexed as

Alzheimer DiseaseBrainMonkey DiseasesPapio hamadryasAgingAnimalsFemaleAlzheimer diseaseAβ plaqueglial tauHamadryasneurofibrillary tanglesneuropathology

Identifiers

PMID39231785
PMCPMC11450389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.