Evidence map›Paper›PMID 39231671›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Spontaneous Regression of Adult Multi-system Langerhans Cell Histiocytosis Presenting as Liver Tumor Rupture.

Seigi Oshima, Shojiro Inano, Gen Honjo, Sumie Tabata, Masakazu Fujimoto, Hironori Haga, Toshiyuki Kitano

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seigi OshimaDepartment of Hematology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Japan.
Shojiro InanoDepartment of Hematology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Japan.
Gen HonjoDepartment of Pathology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Japan.
Sumie TabataDepartment of Hematology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Japan.
Masakazu FujimotoDepartment of Pathology, Kyoto University, Japan.
Hironori HagaDepartment of Pathology, Kyoto University, Japan.
Toshiyuki KitanoDepartment of Hematology, Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult multisystem Langerhans cell histiocytosis (MS-LCH) is rare and has a poor prognosis. A 67-year-old man with MS-LCH presented with a hepatic tumor rupture and multiple masses in the lungs, liver, and pancreas. Despite the initial aggressive disease course and involvement of organs at risk, the patient experienced spontaneous regression and lesion disappearance following smoking cessation without chemotherapy. A literature review revealed a distinct subset of MS-LCH that can be managed by smoking cessation and careful observation through follow-up imaging. This suggests that careful observation through follow-up imaging may be a reasonable alternative to chemotherapy in select adult cases of MS-LCH.

Indexed as

Histiocytosis, Langerhans-CellLiver NeoplasmsAgedHumansMaleRemission, SpontaneousRupture, SpontaneousSmoking Cessationmulti-system Langerhans cell histiocytosisrupture of liver tumorsmoking cessationspontaneous regression

Identifiers

PMID39231671
PMCPMC12097838

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.