Evidence map›Paper›PMID 39231653›Full record

ArticleJournal of atherosclerosis and thrombosis2025

Cerebral Small Vessel Disease is Associated with Prehospital Delay in Acute Ischemic Stroke.

Marina Masui, Takeo Sato, Motohiro Okumura, Takahiro Ishikawa, Kenichi Sakuta, Tatsushi Kokubu, Junichiro Takahashi, Tomomichi Kitagawa, Maki Tanabe, Asako Onda and 5 more

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In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Marina MasuiDepartment of Neurology, The Jikei University School of Medicine.
Takeo SatoDepartment of Neurology, The Jikei University School of Medicine.
Motohiro OkumuraDepartment of Neurology, The Jikei University School of Medicine.
Takahiro IshikawaDepartment of Neurology, The Jikei University School of Medicine.
Kenichi SakutaDepartment of Neurology, The Jikei University School of Medicine.
Tatsushi KokubuDepartment of Neurology, The Jikei University School of Medicine.
Junichiro TakahashiDepartment of Neurology, The Jikei University School of Medicine.
Tomomichi KitagawaDepartment of Neurology, The Jikei University School of Medicine.
Maki TanabeDepartment of Neurology, The Jikei University School of Medicine.
Asako OndaDepartment of Neurology, The Jikei University School of Medicine.
Teppei KomatsuDepartment of Neurology, The Jikei University School of Medicine.
Kenichiro SakaiDepartment of Neurology, The Jikei University School of Medicine.
Tadashi UmeharaDepartment of Neurology, The Jikei University School of Medicine.
Hidetaka MitsumuraDepartment of Neurology, The Jikei University School of Medicine.
Yasuyuki IguchiDepartment of Neurology, The Jikei University School of Medicine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine whether the severity of cerebral small vessel disease (SVD) is associated with prehospital delay in acute ischemic stroke.

methodsConsecutive patients with ischemic stroke were included in this study. We evaluated the SVD burden using the total SVD score. Patients were divided into 2 groups: onset-to-door time within 4.5 hours (early arrival group) and onset-to-door time over 4.5 hours (delayed arrival group). First, we assessed whether the total SVD score was related to prehospital delay using a logistic regression analysis. Second, we assessed which item of the score was independently associated with delays. Finally, we determined whether the item had a linear association with the delay.

resultsOf the 2,112 screened patients, 1,754 were enrolled in the study (1,253 males [71%]; median age, 69 years). There were 1,105 patients (63%) in the delayed arrival group. The total SVD score was independently associated with delay (OR 1.11, 95% CI 1.01-1.21, p=0.025). Among the 4 items of the score, only enlarged perivascular spaces (EPVS) in the basal ganglia was independently associated with delay (OR 1.37, 95% CI 1.05-1.80, p=0.022). A linear trend was observed between EPVS grade and delay with reference to EPVS grade 0-1 (EPVS grade 2: OR 1.22, 95% CI 0.92-1.62, p=0.170, EPVS grade 3: OR 1.69, 95% CI 1.20-2.38, p=0.002, EPVS grade 4: OR 2.17, 95% CI 1.37-3.44, p=0.001).

conclusionsPrehospital delay in acute ischemic stroke could be associated with the severity of SVD, particularly EPVS in the basal ganglia.

Indexed as

Cerebral Small Vessel DiseasesEmergency Medical ServicesIschemic StrokeTime-to-TreatmentAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisSeverity of Illness IndexTime FactorsAcute ischemic strokeCerebral small vessel diseaseEnlarged perivascular spacesOnset-to-door timePrehospital delay

Identifiers

PMID39231653
PMCPMC11802253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.