ArticleNature2024
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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55citing papers in PubMed, 1 pooled it
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Practice Guideline on the Pharmacological Management of Antipsychotic-Related Dyslipidemia.Schizophrenia bulletin · 2026Guideline
- Effect of 2 Weeks of Time-Restricted Eating on Innate Immunity and Systemic Inflammation in Patients With a History of Myocardial Infarction: A Randomized-Controlled Crossover Study.Journal of the American Heart Association · 2026Trial
- Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution inCirculation · 2026Article
- Nrf2 deficiency in myeloid cells accelerates atherosclerosis by promoting the inflammatory response and impairing efferocytosis.Journal of advanced research · 2026Article
- A landscape of metabolic burden and its cardiovascular impact across the adult lifespan: a prospective cohort study of 7.5 million people in Northwestern China.The Lancet regional health. Western Pacific · 2026Article
- Dietary Periodicity Disrupts the Gut Microbiota-Enterolactone Axis to Exacerbate MASLD in a Translational Guinea Pig Model.Nutrients · 2026Article
- Hsa_circ_0044097 Serves as a Promising Biomarker of Atherosclerosis and Its Effects on Vascular Smooth Cell Proliferation and Migration.Journal of biochemical and molecular toxicology · 2026Article
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability.European heart journal · 2026Article
- Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulation in macrophages.Inflammation and regeneration · 2026Review
- A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques.Bioactive materials · 2026Article
- Prevalence and risk factor analysis of early-onset dyslipidemia-a cross-sectional study of 3.7 million population.Lipids in health and disease · 2026Article
- Screening of atherosclerosis diagnostic markers based on lymphangiogenesis-related genes and analysis of immunological characteristics.Journal of cardiothoracic surgery · 2026Article
- Metabolic Perspective on Atherosclerosis: Macrophage Reprogramming and Novel Therapeutic Targets.Journal of the American Heart Association · 2026Review
- ANGWC Nomogram for Predicting Poor 3-month Outcome after Intravenous Thrombolysis in Young and Middle-Aged Patients with First-Ever Stroke.Thrombosis and haemostasis · 2026Article
- Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export.The EMBO journal · 2026Article
- Fucosterol from marine algae: a multifunctional marine phytosterol with health benefits-from dietary component to functional ingredient.Food chemistry: X · 2026Review
- CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Cell type-specific contribution of low-density lipoprotein receptor to atherosclerosis.Science China. Life sciences · 2026Article
- Sparcl1 mitigates abdominal aortic aneurysm through inhibiting lymphangiogenesis-mediated TLS formation.Nature immunology · 2026Article
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Authors and funding
41 authors.
Minoru TakaokaDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0002-8515-8282
Xiaohui Zhao *Department of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0001-9922-2815
Hwee Ying Lim *Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Costan G Magnussen *Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.ORCID 0000-0002-6238-5730
Owen AngImmunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-7210-1586
Nadine SuffeeUniversité Paris Cité, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.ORCID 0000-0001-9277-5089
Patricia R SchrankDepartment of Integrative Biology & Physiology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.
Wei Siong OngImmunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Dimitrios TsiantoulasDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0002-7743-3192
Felix SommerInstitute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig Holstein (UKSH), Kiel, Germany.ORCID 0000-0002-6545-3487
Sarajo K MohantaInstitute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.ORCID 0000-0001-6144-4092
James HarrisonDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0003-4960-5062
Yaxing MengBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Ludivine LauransUniversité Paris Cité, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.
Feitong WuBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Yuning LuDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
Leanne MastersDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
Stephen A NewlandDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
Laura DentiInstitute of Ophthalmology, University College London, London, UK.ORCID 0000-0002-6000-5765
Mingyang HongInstitute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
Mouna ChajadineUniversité Paris Cité, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.
Markus JuonalaDepartment of Medicine, University of Turku, Turku, Finland.ORCID 0000-0001-9498-364X
Juhani S KoskinenResearch Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.ORCID 0000-0002-5920-9728
Mika KähönenDepartment of Clinical Physiology, University of Tampere, Tampere, Finland.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Suvi P RovioResearch Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Juha MykkänenResearch Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.ORCID 0000-0001-9898-2660
Russell ThomsonBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Tsuneyasu KaishoDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.ORCID 0000-0003-2616-1665
Andreas J R HabenichtInstitute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.ORCID 0000-0003-2901-3027
Marc ClementDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0002-6479-8360
Alain TedguiUniversité Paris Cité, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.ORCID 0000-0002-7229-4875
Hafid Ait-OufellaUniversité Paris Cité, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.ORCID 0000-0002-2955-0183
Tian X ZhaoDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0003-0202-5255
Meritxell NusDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.ORCID 0000-0002-6378-8910
Christiana RuhrbergInstitute of Ophthalmology, University College London, London, UK.ORCID 0000-0002-3212-9381
Soraya TalebUniversité Paris Cité, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.ORCID 0000-0002-6650-619X
Jesse W WilliamsDepartment of Integrative Biology & Physiology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-3815-0891
Olli T Raitakari *Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Véronique Angeli *Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-2759-3497
Ziad MallatDepartment of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK. zm255@medschl.cam.ac.uk.ORCID 0000-0003-0443-7878
Funding
Sex and stress hormones control adrenal gland macrophage development and function"R01AI165553 · NIAID · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2022 to 2025
$2.2MNIAID NIH HHS R01 AI165553Wellcome Trust
Abstract
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk
Indexed as
AtherosclerosisDiet, WesternHyperlipidemiasMacrophagesAdolescentAdultAnimalsChildChild, PreschoolCholesterol, LDLFemaleFinlandGenome-Wide Association StudyHumansIncidenceMaleCholesterol, LDL
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.