ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024
Assessment of the Addition of Oxaliplatin to Fluoropyrimidine-Based Adjuvant Chemotherapy in Patients With High-Risk Stage II Colon Cancer: An ACCENT Pooled Analysis.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Chinese herbal medicine (JianPi-BuShen) and completion rate of adjuvant chemotherapy for patients with stage II and III colon cancer: A randomized clinical trial.European journal of cancer (Oxford, England : 1990) · 2024Trial
- Deep learning-driven MRI radiomics reveals biological subtypes and predicts recurrence risk in rectal cancer.NPJ precision oncology · 2026Article
- Three Versus 6 Months of Adjuvant Oxaliplatin-Fluoropyrimidine Chemotherapy for Colorectal Cancer: Final Results of SCOT-An International, Randomized, Phase III, Noninferiority Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026Article
- Article
- Bridging the Evidence Gap: A Retrospective Lens on Survival and Treatment Patterns in Older Patients With Colorectal Cancer.Saudi medical journal · 2026Article
- Implementing Immunoscore in colorectal cancer: lessons from cohort studies, limitations and barriers to adoption.The journal of pathology. Clinical research · 2026Review
- Age-related differences in adjuvant chemotherapy use and outcomes in stage II colon cancer: a retrospective cohort study.BMC cancer · 2025Article
- Colorectal cancer care in Tanzania: an evaluation of clinical characteristics, treatment patterns and quality metrics at a national cancer referral hospital.Ecancermedicalscience · 2025Article
- The clinical dilemma of high-risk stage II colon cancer: are we truly prepared to withdraw oxaliplatin?ESMO open · 2024Article
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Funding
Abstract
purposeThe adjuvant treatment for stage III colon cancer (CC) is chemotherapy combining fluoropyrimidine (FP) and oxaliplatin (OX). FP regimen plus OX (FPOX) may benefit in high-risk stage II CC. We performed a pooled analysis of pivotal MOSAIC and C-07 studies evaluating FPOX for the treatment of high-risk stage II CC according to prognostic factors, number of high-risk factors, and current clinicopathologic risk classification on the basis of T stage, tumor perforation, and number of lymph nodes examined. PATIENTS AND
methodsOne thousand five hundred and ninety-five patients with stage II CC receiving FP or FPOX were pooled. The overall survival (OS) benefit of OX was analyzed using Kaplan-Meier curves and unadjusted Cox models stratified by study. Three thousand and fifty-nine patients with stage III CC were used only for interaction tests between the allocated chemotherapy and stage.
resultsIn the pooled analysis of stage II patients, independent prognostic factors in multivariable analysis were sex, age, perforation/obstruction, and tumor sidedness. There was a significant interaction in OS between stage and allocated chemotherapy with hazard ratios (HRs) of 1.03 for stage II (95% CI, 0.82 to 1.29;
conclusionNo OS benefit of adjuvant OX was found in high-risk stage II CC, regardless of the definition used to characterize tumors as having a high risk for recurrence. Hence, our analysis suggests that OX should not be the standard of care for adjuvant chemotherapy for stage II CC, even in high-risk patients.
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