Evidence map›Paper›PMID 39231381›Full record

ArticleNeurology2024

Association of Urinary Cadmium Concentration With Cognitive Impairment in US Adults: A Longitudinal Cohort Study.

Liping Lu, Yijia Zhang, Meghan Angley, Shai Bejerano, John D Brockman, Leslie A McClure, Frederick W Unverzagt, Alyce D Fly, Ka Kahe

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Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liping LuFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-5110-1923
Yijia ZhangFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-6638-2641
Meghan AngleyFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.
Shai BejeranoFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.
John D BrockmanFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.
Leslie A McClureFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0002-2465-6739
Frederick W UnverzagtFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.
Alyce D FlyFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.
Ka KaheFrom the Department of Obstetrics and Gynecology (L.L., Y.Z., M.A., S.B., K.K.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (L.L., Y.Z., M.A., K.K.), Mailman School of Public Health, Columbia University, New York, NY; Department of Nutrition and Health Science (L.L., A.D.F.), College of Health, Ball State University, Muncie, IN; Department of Chemistry (J.D.B.), University of Missouri, Columbia; College for Public Health & Social Justice (L.A.M.), Saint Louis University, MO; and Department of Psychiatry (F.W.U.), Indiana University School of Medicine, Indianapolis.ORCID 0000-0001-5078-2010

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
NIA NIH HHS RF1 AG056111NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

BACKGROUND AND

objectivesStudies have indicated that cadmium (Cd) exposure is associated with neurotoxicity. However, data linking Cd exposure to cognitive impairment are sparse. We aimed to investigate the association between urinary Cd concentration and cognitive impairment in US adults.

methodsThe REasons for Geographic and Racial Differences in Stroke (REGARDS) study is an ongoing population-based prospective cohort study that enrolled 30,239 Black and White US adults aged 45 years or older at baseline (2003-2007). In a randomly selected subcohort of REGARDS participants who were free of cognitive impairment or stroke at baseline, certain trace element concentrations, including urinary creatinine-corrected Cd, were measured using biospecimens collected and stored at baseline. During an average of 10 years of follow-up, global cognitive impairment was assessed annually using the Six-Item Screener, and domain-based cognitive impairment, including verbal learning, memory, and executive function, was evaluated every other year using the Enhanced Cognitive Battery. Multivariable-adjusted logistic regression models were used to examine the association between urinary Cd concentration and the odds of global or domain-based cognitive impairment.

resultsA total of 2,172 participants (mean age: 64.1 ± 9.0 years; female: 54.8%; Black participants: 38.7%) with available data on urinary Cd concentration, including 195 cases of global cognitive impairment and 53 cases of domain-based cognitive impairment, were included in the analyses. While there was no association between Cd and cognitive impairment in the full sample, there was a significant positive association of urinary Cd concentration with global cognitive impairment among White but not Black participants. The odds of cognitive impairment for White participants in the high urinary Cd concentration group (≥median) were doubled compared with those in the low urinary Cd group (odds ratio 2.07, 95% CI 1.18-3.64). Sex, age, region, smoking pack-years, alcohol consumption, and other related metals did not materially modify the associations of interest. DISCUSSION: Findings from this prospective cohort study suggest that urinary Cd concentrations are associated with global cognitive impairment among White but not Black individuals. Further studies with repeatedly measured Cd exposure, larger sample sizes, and longer duration are needed to confirm our findings and explore the potential explanations for the observed racial discrepancy, such as the impact of smoking.

Indexed as

CadmiumCognitive DysfunctionAgedBlack or African AmericanCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesUnited StatesWhiteCadmium

Identifiers

PMID39231381
PMCPMC11373676

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.