Evidence map›Paper›PMID 39231215›Full record

ArticleScience advances2024

A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in

Hila Zak, Eyal Rozenfeld, Mali Levi, Patricia Deng, David Gorelick, Hadar Pozeilov, Shai Israel, Yoav Paas, Yoav Paas, Jin Billy Li and 2 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Promiscuous RNA editing in lncRNARNA (New York, N.Y.) · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hila ZakThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
Eyal RozenfeldDepartment of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0001-5316-0495
Mali LeviThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
Patricia DengDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-9717-4143
David GorelickThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.ORCID 0000-0003-1124-3916
Hadar PozeilovThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
Yoav PaasDepartment of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Yoav PaasThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
Jin Billy LiDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0713-1399
Moshe ParnasDepartment of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0001-9726-1511
Galit Shohat-OphirThe Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.ORCID 0000-0003-1246-1827

Funding

Regulatory and Mechanistic Understanding of ADAR-Mediated RNA EditingR35GM144100 · NIGMS · STANFORD UNIVERSITY · PI Jin Billy Li · 2022 to 2026
$3.2M
NIGMS NIH HHS R35 GM144100
6 · The paper itself

Abstract

A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which are recognized as guanosines by cellular machinery. Despite the vast number of editing sites observed across the animal kingdom, pinpointing critical sites and understanding their in vivo functions remains challenging. Here, we study the function of an evolutionary conserved editing site in

Indexed as

Chloride ChannelsRNA EditingAdenosineAnimalsBehavior, AnimalDrosophilaDrosophila melanogasterDrosophila ProteinsInosineOdorantsSmellAdenosineChloride ChannelsDrosophila Proteinsglutamate-gated chloride channelsInosine

Identifiers

PMID39231215
PMCPMC11373593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.