Evidence map›Paper›PMID 39231207›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.

Wenguang He, Geneviève M C Gasmi-Seabrook, Mitsuhiko Ikura, Jeffrey E Lee, Michael Ohh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenguang HeDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0009-0004-1628-0534
Geneviève M C Gasmi-SeabrookPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Mitsuhiko IkuraPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Jeffrey E LeeDepartment of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-2172-6586
Michael OhhDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1M1, Canada.ORCID 0000-0001-7600-4751

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-159773Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-191811
6 · The paper itself

Abstract

Prolyl-hydroxylation is an oxygen-dependent posttranslational modification (PTM) that is known to regulate fibril formation of collagenous proteins and modulate cellular expression of hypoxia-inducible factor (HIF) α subunits. However, our understanding of this important but relatively rare PTM has remained incomplete due to the lack of biophysical methodologies that can directly measure multiple prolyl-hydroxylation events within intrinsically disordered proteins. Here, we describe a real-time

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitIntrinsically Disordered ProteinsProlineHumansHydroxylationMagnetic Resonance SpectroscopyProtein Processing, Post-TranslationalHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIntrinsically Disordered ProteinsProline13C-direct detection NMRhypoxia-inducible factorintrinsically disordered proteinprolyl-hydroxylation

Identifiers

PMID39231207
PMCPMC11406255

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.