Evidence map›Paper›PMID 39231164›Full record

SynthesisPloS one2024

Efficacy and safety of tranexamic acid on blood loss and seizures in patients undergoing meningioma resection: A systematic review and meta-analysis.

Xiaoyuan Liu, Minying Liu, Shu Li, Yue Ren, Maoyao Zheng, Min Zeng, Yuming Peng

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyuan LiuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Minying LiuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shu LiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yue RenDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Maoyao ZhengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Min ZengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuming PengDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-2630-2467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIt is unclear how tranexamic acid (TXA) affects blood loss and seizures in meningioma resections. We performed a systematic review and meta-analysis and tried to evaluate the effectiveness and safety of TXA use for patients undergoing meningioma resections.

methodsRegards to this systematic review and meta-analysis (registered with CRD42023416693), we searched PubMed, Embase (Ovid), EBSCO, and Cochrane central library up to and including Oct 2023. Patients undergoing meningioma resections treated with TXA and placebo or no treatment were eligible for this study. This would allow delineation of the impact of TXA on blood loss, postoperative seizure, and other complication incidences.

resultsFour prospective cohort studies with 781 patients (390 patients in the TXA group and 391 patients in the control group) were conducted via a systematic review and meta-analysis. The results suggested that the application of TXA for patients undergoing meningioma resections reduced mean blood loss of 252 mL with 95% confidence interval (CI) -469.26 to -34.67 (P = 0.02) and I2 of 94% but did not increase postoperative seizure (risk ratio: 1.08; 95%CI: 0.54 to 2.15; P = 0.84) and other complication rates.

conclusionsThis systematic review and meta-analysis suggests that the administration of TXA could reduce blood loss in patients undergoing intracerebral meningioma resection. REGISTRY INFORMATION: The systematic review protocol has been registered at PROSPERO (Registration No. CRD42023416693) on April 23, 2023.

Indexed as

Blood Loss, SurgicalMeningiomaSeizuresTranexamic AcidAntifibrinolytic AgentsHumansMeningeal NeoplasmsPostoperative ComplicationsTreatment OutcomeAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID39231164
PMCPMC11373793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.