Evidence map›Paper›PMID 39230828›Full record

ArticleInfectious diseases and therapy2024

Mycoplasma hominis as Cause of Extragenital Infection in Patients with Hypogammaglobulinemia: Report of 2 Cases and Literature Review.

Chiara Russo, Malgorzata Mikulska, Emanuele Delfino, Federica Toscanini, Laura Mezzogori, Riccardo Schiavoni, Claudia Bartalucci, Emanuele Angelucci, Giulia Bartalucci, Massimiliano Gambella and 7 more

Abstract read
In one paragraph

Article in Infectious diseases and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Hyperammonaemic encephalopathy and subsequent arthritis due to Ureaplasma urealyticum in a haematopoietic cell transplant recipient: a case report and literature review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Persistent Pyelonephritis and Renal Abscess due toCase reports in infectious diseases · 2026
    Article
  3. ExtragenitalIDCases · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chiara Russo *Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Malgorzata Mikulska *Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. m.mikulska@unige.it.
Emanuele DelfinoInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, L.Go R. Benzi, 10, 16132, Genoa, Italy.
Federica ToscaniniInfectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, L.Go R. Benzi, 10, 16132, Genoa, Italy.
Laura MezzogoriDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Riccardo SchiavoniDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Claudia BartalucciDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Emanuele AngelucciHematology and Transplant Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giulia BartalucciHematology and Transplant Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Massimiliano GambellaHematology and Transplant Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Anna Maria RaiolaHematology and Transplant Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Paola MoriciMicrobiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Francesca CreaMicrobiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Silvia ChiolaNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Silvia Daniela MorbelliNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Anna MarcheseMicrobiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Matteo BassettiDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycoplasma hominis can be a part of human urogenital tract microbiome, and it is a frequent cause of urogenital infections. In rare cases, it can also cause extragenital infections, especially in immunocompromised patients. In this case series, we report two cases and provide a literature review of extragenital infections caused by M. hominis in patients with hypogammaglobulinemia. Patient 1 was a 61-year-old woman with diffuse large B-cell lymphoma who, after rituximab-containing chemotherapy and CAR-T therapy, developed M. hominis spondylodiscitis. Patient 2 was a 50-year-old woman with congenital hypogammaglobulinemia who developed disseminated M. hominis infection involving pleura, muscles, and right ankle. Antibiotic therapy with levofloxacin and doxycycline for 10 weeks in patient 1 and with levofloxacin alone for 6 weeks in patient 2 led to infection resolution. The literature review identified 14 additional cases reporting M. hominis extragenital infection in patients with hypogammaglobulinemia. M. hominis should also be suspected as an etiological agent of extragenital infection in patients with B-cell immunodeficiency with a clinical picture of persistent, standard-culture negative infection, particularly with arthritis or abscess formation. Even if M. hominis can grow on standard bacterial medium, in suspected cases molecular methods should be promptly used for correct diagnostic work-up and successful therapy.

Indexed as

Extragenital infectionHypogammaglobulinemiaMycoplasma hominis

Identifiers

PMID39230828
PMCPMC11416451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.