Evidence map›Paper›PMID 39230803›Full record

ArticleJournal of neuro-oncology2024

Frailty indices predict mortality, complications and functional improvements in supratentorial meningioma patients over 80 years of age.

Christoph Schwartz, Moritz F Ueberschaer, Ilari Rautalin, Jürgen Grauvogel, Marco Bissolo, Waseem Masalha, Christine Steiert, Oliver Schnell, Jürgen Beck, Florian Ebel and 20 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Christoph SchwartzDepartment of Neurosurgery, Helsinki University and Helsinki University Hospital, Helsinki, Finland. c.schwartz@salk.at.
Moritz F UeberschaerDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Ilari RautalinDepartment of Neurosurgery, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Jürgen GrauvogelDepartment of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.
Marco BissoloDepartment of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.
Waseem MasalhaDepartment of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.
Christine SteiertDepartment of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.
Oliver SchnellDepartment of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.
Jürgen BeckDepartment of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.
Florian EbelDepartment of Neurosurgery, Inselspital, Bern University-Hospital, Bern, Switzerland.
David BerviniDepartment of Neurosurgery, Inselspital, Bern University-Hospital, Bern, Switzerland.
Andreas RaabeDepartment of Neurosurgery, Inselspital, Bern University-Hospital, Bern, Switzerland.
Thomas EiblDepartment of Neurosurgery, Paracelsus Medical University, Klinikum Nuremberg, Nuremberg, Germany.
Hans-Herbert SteinerDepartment of Neurosurgery, Paracelsus Medical University, Klinikum Nuremberg, Nuremberg, Germany.
Karl-Michael SchebeschDepartment of Neurosurgery, Paracelsus Medical University, Klinikum Nuremberg, Nuremberg, Germany.
Nathan A ShlobinDepartment of Neurological Surgery, Northwestern University, Chicago, IL, 60601, USA.
Khizar R NandoliyaDepartment of Neurological Surgery, Northwestern University, Chicago, IL, 60601, USA.
Mark W YoungbloodDepartment of Neurological Surgery, Northwestern University, Chicago, IL, 60601, USA.
James P ChandlerDepartment of Neurological Surgery, Northwestern University, Chicago, IL, 60601, USA.
Stephen T MagillDepartment of Neurological Surgery, Northwestern University, Chicago, IL, 60601, USA.
Alexander RomagnaDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Jens LehmbergDepartment of Neurosurgery, München Klinik Bogenhausen, Munich, Germany.
Manuel FuetschDivision of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Julian SpearsDivision of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Arwin RezaiDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Barbara LadisichDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Matthias DemetzDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Christoph J GriessenauerDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Mika NiemeläDepartment of Neurosurgery, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
Miikka KorjaDepartment of Neurosurgery, Helsinki University and Helsinki University Hospital, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess whether the Modified 5 (mFI-5) and 11 (mFI-11) Factor Frailty Indices associate with postoperative mortality, complications, and functional benefit in supratentorial meningioma patients aged over 80 years.

methodsBaseline characteristics were collected from eight centers. Based on the patients' preoperative status and comorbidities, frailty was assessed by the mFI-5 and mFI-11. The collected scores were categorized as "robust (mFI=0)", "pre-frail (mFI=1)", "frail (mFI=2)", and "significantly frail (mFI≥3)". Outcome was assessed by the Karnofsky Performance Scale (KPS); functional benefit was defined as improved KPS score. Additionally, we evaluated the patients' functional independence (KPS≥70) after surgery.

resultsThe study population consisted of 262 patients (median age 83 years) with a median preoperative KPS of 70 (range 20 to 100). The 90-day and 1-year mortality were 9.0% and 13.2%; we recorded surgery-associated complications in 111 (42.4%) patients. At last follow-up within the postoperative first year, 101 (38.5%) patients showed an improved KPS, and 183 (69.8%) either gained or maintained functional independence. "Severely frail" patients were at an increased risk of death at 90 days (OR 16.3 (CI95% 1.7-158.7)) and one year (OR 11.7 (CI95% 1.9-71.7)); nine (42.9%) of severely frail patients died within the first year after surgery. The "severely frail" cohort had increased odds of suffering from surgery-associated complications (OR 3.9 (CI 95%) 1.3-11.3)), but also had a high chance for postoperative functional improvements by KPS≥20 (OR 6.6 (CI95% 1.2-36.2)).

conclusionThe mFI-5 and mFI-11 associate with postoperative mortality, complications, and functional benefit. Even though "severely frail" patients had the highest risk morbidity and mortality, they had the highest chance for functional improvement.

Indexed as

FrailtyMeningeal NeoplasmsMeningiomaPostoperative ComplicationsAged, 80 and overFemaleFollow-Up StudiesFrail ElderlyHumansKarnofsky Performance StatusMalePrognosisRetrospective StudiesSupratentorial NeoplasmsElderlyFunctional outcomeMeningiomaModified 5 (mFI-5) and 11 (mFI-11) Factor Frailty IndicesMortality

Identifiers

PMID39230803
PMCPMC11447097

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.