Evidence map›Paper›PMID 39230780›Full record

ArticleJournal of autism and developmental disorders2026

Contributions of the ELENA Cohort to Study Autism Spectrum Disorder in Children and Adolescents from a Biopsychosocial Framework.

Amaria Baghdadli, Marianne Peries, Julie Loubersac, Cécile Michelon, Cécile Rattaz, Laetitia Ferrando, Aurore David, Kerim Munir, Marie-Christine Picot

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amaria BaghdadliCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France. rech-clinique-autisme@chu-montpellier.fr.ORCID http://orcid.org/0000-0002-5679-7544
Marianne PeriesCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France.ORCID http://orcid.org/0000-0002-6791-4419
Julie LoubersacCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France.ORCID http://orcid.org/0000-0002-2771-0577
Cécile MichelonCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France.
Cécile RattazCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France.
Laetitia FerrandoCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France.
Aurore DavidCentre de Ressource Autisme Languedoc-Roussillon & Centre d'Excellence sur l'Autisme et les Troubles Neurodéveloppementaux (CeAND), CHU Montpellier, 39 Avenue Charles Flahaut, 34295, Montpellier Cedex 05, France.
Kerim MunirDevelopmental Medicine Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2404-1806
Marie-Christine PicotCentre d'Excellence sur l'Autisme et les Troubles du Neurodéveloppement (CeAND), CHU Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0003-4204-7299

Funding

Caisse nationale de solidarité pour l'autonomie 030319Direction Générale de l'offre de Soins 13-0232
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by a myriad of developmental, biological, psychological, and socio-demographic factors. The ELENA cohort seeks to delineate the intricate interplay of these factors, facilitating the identification of risk factors and the development of targeted interventions. This paper emphasizes the clinical profiles of children and outlines key findings from a biopsychosocial perspective. The ELENA cohort, a multicenter initiative across French regional centers, conducted a systematic prospective analysis on children newly diagnosed with DSM-5 ASD between 2012 and 2019. This encompassed direct assessments and parent-reported questionnaires covering a broad spectrum of developmental, biological, psychological and socio-demographic measures. Embedded case-control studies further examined risk and protective factors, alongside specific environmental and psychosocial influences during pregnancy and early childhood. A subset of participants also contributed biospecimens, with data enhancement via linkage to French National Administrative Healthcare Databases. The study unveils baseline clinical characteristics for 876 children, average age 6 (SD ± 3.3) previously unreported in protocol descriptions. It highlights the study's developmental biopsychosocial approach and its novel findings on children's socio-adaptive functioning, ASD severity, comorbidities, quality of life and interventions. Employing developmental biopsychosocial insights offers a promising pathway to integrating health, social care, and experiential insights, ultimately aiming to enhance the future well-being and outcomes for children with ASD. This approach underscores the need of a holistic, interdisciplinary strategy in encouraging and supporting the ASD community.

Indexed as

Autism Spectrum DisorderModels, BiopsychosocialAdolescentCase-Control StudiesChildChild, PreschoolCohort StudiesFemaleFranceHumansMaleProspective StudiesQuality of LifeRisk FactorsAutism spectrum disorderBiopsychosocialCohortDevelopmental coursePrognosis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.