Evidence map›Paper›PMID 39230659›Full record

ArticleJournal of cardiovascular translational research2025

AIM2 Deficiency Alleviates Cardiac Inflammation and Hypertrophy in HFD/STZ-Induced Diabetic Mice by Inhibiting the NLRC4/IRF1 Signaling Pathway.

Jian-Ping Wu, Cheng Wu, Yuan-Ji Ma, Jian-Bing Zhu, Lei-Lei Ma, Fei-Juan Kong

Erratum issuedAbstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. PANoptosis: a potential target of atherosclerotic cardiovascular disease.Apoptosis : an international journal on programmed cell death · 2025
    Review
  6. Review
  7. The role of AIM2 in inflammation and tumors.Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jian-Ping Wu *Department of Anesthesiology and Pain Medicine, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Cheng Wu *Department of Anesthesiology and Pain Medicine, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Yuan-Ji Ma *Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Yi Xue Yuan Rd, Xu Hui District, Shanghai, 200032, China.
Jian-Bing ZhuDepartment of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Yi Xue Yuan Rd, Xu Hui District, Shanghai, 200032, China.
Lei-Lei MaDepartment of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Yi Xue Yuan Rd, Xu Hui District, Shanghai, 200032, China. mllsdjn@126.com.
Fei-Juan KongDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wu Jin Rd, Hong Kou District, Shanghai, 200032, China. kongfeijuan@163.com.ORCID 0000-0001-8001-5365

Funding

Natural Science Foundation of Shanghai Municipality 21ZR1451300
6 · The paper itself

Abstract

Absent in melanoma 2(AIM2) exacerbates atherosclerosis by inflammasome assembly. However, AIM2-mediated inflammation in diabetic cardiomyopathy remains incompletely understood. Here we investigate the role of AIM2 in high glucose (HG)- and diabetes-induced inflammatory cardiomyopathy. By RNA-seq, we found that AIM2 were significantly upregulated in HG-induced macrophages, upregulation of AIM2 in cardiac infiltrating macrophages was confirmed in a high-fat diet (HFD)/streptozotocin (STZ)-induceddiabetic mouse model . Therefore, AIM2 knockout mice were constructed. Compared to WT mice, HFD/STZ-induced cardiac hypertrophy and dysfunction were significantly improved in AIM2

Indexed as

Apoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsDiabetes Mellitus, ExperimentalDiabetic CardiomyopathiesDNA-Binding ProteinsHypertrophy, Left VentricularInflammasomesInterferon Regulatory Factor-1Myocytes, CardiacVentricular RemodelingAnimalsDiet, High-FatInflammation MediatorsMacrophagesMaleAim2 protein, mouseApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsDNA-Binding ProteinsInflammasomesInflammation MediatorsInterferon Regulatory Factor-1Ipaf protein, mouseIrf1 protein, mouseAIM2Diabetic cardiomyopathyIRF1Macrophage polarization

Identifiers

PMID39230659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.