Evidence map›Paper›PMID 39230617›Full record

SynthesisAIDS and behavior2025

Identifying Effective Strategies for Improving Engagement in HIV Prevention and Care Among Transgender Persons in the United States: A Systematic Review.

Nicole Crepaz, Olivia Peters, Darrel H Higa, Mary M Mullins, Charles B Collins

Abstract readSystematic Review
In one paragraph

Synthesis in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. HIV Self-Test Experiences and Implementation Considerations Among Transgender Women in the Philippines: Getting Ready for Scale-Up.AIDS education and prevention : official publication of the International Society for AIDS Education · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole CrepazDivision of HIV Prevention, The U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd., MS H24-5, Atlanta, GA, 30333, USA. ncrepaz@cdc.gov.ORCID http://orcid.org/0000-0002-6940-9846
Olivia PetersUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Darrel H HigaDivision of HIV Prevention, The U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd., MS H24-5, Atlanta, GA, 30333, USA.
Mary M MullinsDivision of HIV Prevention, The U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd., MS H24-5, Atlanta, GA, 30333, USA.
Charles B CollinsDivision of HIV Prevention, The U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd., MS H24-5, Atlanta, GA, 30333, USA.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

This systematic review synthesized published literature (2000 - 2023) to identify HIV interventions specifically designed for transgender persons in the United States (PROSPERO registration number: CRD42021256460). The review also summarized strategies for improving outcomes related to the four pillars of the Ending the HIV Epidemic (EHE) initiative in the United States: Diagnose, Treat, Prevent, and Respond. A comprehensive search was conducted using the Centers for Disease Control and Prevention's HIV Prevention Research Synthesis Project database, which included over 120,000 citations from routine systematic searches in CINAHL, EMBASE, Global Health, MEDLINE, PsycInfo, and Sociological Abstracts. Of 23 interventions that met inclusion criteria, 94% focused on transgender women of color and 22% focused on young transgender persons aged 15-29 years old. Most interventions focused on Treat or Prevent, few focused on Diagnosis, and none focused on Respond. Twenty interventions (87%) showed improvement in at least one EHE related outcome and a quarter of these effective interventions were tested with randomized controlled trials. Common strategies observed in effective interventions include the following: engaging the community in intervention development; pilot-testing with the focus population to ensure appropriateness and acceptability; addressing social determinants of health (e.g. stigma, discrimination, violence) through empowerment and gender-affirming approaches; increasing access to care, prevention, and services through co-location and one-stop shop models; and utilizing peer-led counseling, education, support, and navigation. Continuous effort is needed in addressing gaps, including more research for transgender men and rural settings and for how best to adopt and adapt best practices for subgroups of transgender population.

Indexed as

HIV InfectionsTransgender PersonsAdolescentAdultFemaleHumansMaleSocial StigmaUnited StatesYoung AdultEvidence-based interventionsHIV care; HIV preventionPre-exposure prophylaxisSystematic reviewTransgender persons

Identifiers

PMID39230617
PMCPMC11747888

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.