Evidence map›Paper›PMID 39230606›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Septoplasty versus non-surgical management for deviated nasal septum: a systematic review and meta-analysis of randomized controlled trials.

Hosam I Taha, Mohamed S Elgendy, Mohamed R Ezz, Khalid Tolba, Mahmoud El Safty, Mohammad Al Diab Al Azzawi, Basant E Katamesh, Ebraheem Albazee

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hosam I Taha *Faculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0009-0008-9192-4175
Mohamed S Elgendy *Faculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0000-0003-3080-2875
Mohamed R EzzFaculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0000-0002-2998-6155
Khalid TolbaFaculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0009-0001-4057-1671
Mahmoud El SaftyFaculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0009-0004-8461-0435
Mohammad Al Diab Al AzzawiFaculty of Medicine, National Ribat University, Khartoum, Sudan.ORCID https://orcid.org/0009-0006-6776-6467
Basant E KatameshFaculty of Medicine, Tanta University, Tanta, Egypt.ORCID https://orcid.org/0000-0001-9992-2387
Ebraheem AlbazeeKuwait Institute for Medical Specializations (KIMS), Kuwait City, Kuwait. Ebraheemalbazee@gmail.com.ORCID http://orcid.org/0000-0003-1244-7769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the efficacy and safety of septoplasty versus non-surgical management for patients experiencing nasal obstruction due to deviated nasal septum (DNS).

methodsWe conducted a comprehensive search of PubMed, Scopus, Embase, Web of Science, Cochrane Library, Clinicaltrials.gov, ICTRP, and ISRCTN for relevant RCTs. The primary outcomes included the Nasal Obstruction Symptom Evaluation (NOSE) scale, Sino-Nasal Outcome Test (SNOT-22), Peak Nasal Inspiratory Flow (PNIF), surgical complications, and quality of life. Data were synthesized using RevMan 5.4 and STATA 18, with effect estimates presented as mean differences (MD) or risk ratios (RR) with 95% confidence intervals (CI). The study protocol was registered with PROSPERO (ID: CRD42024538373).

resultsOur search identified 537 studies, of which 3 RCTs involving 721 participants met the inclusion criteria. The meta-analysis revealed that septoplasty significantly improved NOSE and SNOT-22 scores compared to non-surgical interventions at 6 and 12 months of follow-up, despite no notable differences at 3 months post-treatment. No significant difference was observed regarding nasal flow assessed by PNIF. The rate of complications was low, ranging from 0.31% (revision rate) to 4.12% (bleeding and infection rates). Additionally, our qualitative synthesis showed an improvement in the quality of life at 6 and 12 months in the septoplasty group compared with the non-surgical group.

conclusionsThis systematic review and meta-analysis of 721 patients revealed the efficacy of septoplasty, with or without turbinate surgery, in improving nasal obstruction symptoms at 6 and 12 months. Additionally, septoplasty consists of a relatively low rate of complications such as bleeding, infection, and septal perforation. Furthermore, a low revision rate was found. Septoplasty improved the quality of life, especially after 6 and 12 months. However, our findings should be interpreted with caution, and further research is needed to consolidate our results.

Indexed as

Nasal ObstructionNasal SeptumNose Deformities, AcquiredRhinoplastyHumansQuality of LifeRandomized Controlled Trials as TopicDeviated nasal septumMeta-analysisNasal obstructionNon-surgical managementRCTsSeptoplasty

Identifiers

PMID39230606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.