Evidence map›Paper›PMID 39230311›Full record

ArticleAntimicrobial agents and chemotherapy2024

Clinical outcomes and emergence of resistance of

Dariusz A Hareza, Sara E Cosgrove, Robert A Bonomo, Kathryn Dzintars, Sara M Karaba, Armani M Hawes, Tsigereda Tekle, Patricia J Simner, Pranita D Tamma

Abstract readMulticenter Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Is less always more? Ceftazidime/avibactam alone or in combination to treat infections caused by Pseudomonas aeruginosa: a retrospective observational multi-centre cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  5. Indian Society of Critical Care Medicine Guidelines on Evidence-based Recommendations for the Treatment of Carbapenem-resistant Enterobacterales, Carbapenem-resistantIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  6. Article
  7. Ceftazidime-avibactam resistance evolution inAntimicrobial agents and chemotherapy · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. TheFrontiers in cellular and infection microbiology · 2026
    Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dariusz A HarezaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sara E CosgroveDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert A BonomoDepartments of Medicine, Pharmacology, Molecular Biology, and Microbiology, Medical Service and Center for Antimicrobial Resistance and Epidemiology, Louis Stokes Cleveland Veterans Affairs Medical Center, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X
Kathryn DzintarsDepartment of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
Sara M KarabaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8452-5549
Armani M HawesDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tsigereda TekleDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Patricia J SimnerDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6134-151X
Pranita D TammaDepartments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4143-6324

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
Modifiable Risk Factors for the Emergence of Resistance to Pseudomonas aeruginosaR21AI153580 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TAMMA, PRANITA · 2021 to 2022
$479k
HHS | National Institutes of Health (NIH) R21-AI153580HHS | National Institutes of Health (NIH) T32-AI007291HHS | National Institutes of Health (NIH) UM1AI104681NIAID NIH HHS R21 AI153580NIAID NIH HHS T32 AI007291NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

Few studies compare outcomes of patients with difficult-to-treat resistance (DTR)

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsCeftazidimeCephalosporinsDrug CombinationsMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsTazobactamAgedDrug Resistance, Multiple, BacterialFemaleHumansMaleMiddle AgedProspective StudiesAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsCeftazidimeceftolozane, tazobactam drug combinationCephalosporinsDrug CombinationsTazobactamantimicrobial resistanceceftolozane-tazobactam, ceftazidime-avibactamPDCPseudomonas aeruginosa

Identifiers

PMID39230311
PMCPMC11459953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.