Evidence map›Paper›PMID 39229786›Full record

ArticleFuture oncology (London, England)2024

The INSIGHT study: a randomized, Phase III study of ripretinib versus sunitinib for advanced gastrointestinal stromal tumor with

Suzanne George, Jean-Yves Blay, Ping Chi, Robin L Jones, César Serrano, Neeta Somaiah, Hans Gelderblom, John R Zalcberg, William Reichmann, Kam Sprott and 5 more

Abstract readClinical Trial Protocol
In one paragraph

Article in Future oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Observational
  3. Updated Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor (2025).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Review
  4. Review
  5. Review
  6. Molecular Mechanisms and Clinical Implications ofCurrent issues in molecular biology · 2025
    Review
  7. Clinical impact of primary and secondary KIT mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Suzanne GeorgeDana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0002-1284-8493
Jean-Yves BlayCentre Léon Bérard, Lyon, 69008, France.ORCID 0000-0001-7190-120X
Ping ChiMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-0159-5531
Robin L JonesSarcoma Unit, The Royal Marsden NHS Foundation Trust & Institute of Cancer Research, London, SW3 6JJ, UK.ORCID 0000-0003-4173-3844
César SerranoVall d'Hebron Institute of Oncology, Barcelona, 08035, Spain.ORCID 0000-0003-1416-8739
Neeta SomaiahThe University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-0146-7732
Hans GelderblomLeiden University Medical Center, Leiden, 2333 ZA, Netherlands.ORCID 0000-0001-9270-8636
John R ZalcbergMonash University School of Public Health & Preventive Medicine & Department of Medical Oncology, Alfred Health, Melbourne, Victoria, 3004, Australia.ORCID 0000-0002-6624-0782
William ReichmannDeciphera Pharmaceuticals, LLC, Waltham, MA 02451, USA.ORCID 0009-0006-9954-2740
Kam SprottDeciphera Pharmaceuticals, LLC, Waltham, MA 02451, USA.ORCID 0009-0006-3712-8114
Paulina CoxDeciphera Pharmaceuticals, LLC, Waltham, MA 02451, USA.ORCID 0009-0001-2565-3169
Matthew L ShermanDeciphera Pharmaceuticals, LLC, Waltham, MA 02451, USA.ORCID 0009-0009-4646-5819
Rodrigo Ruiz-SotoDeciphera Pharmaceuticals, LLC, Waltham, MA 02451, USA.ORCID 0000-0003-3057-7735
Michael C HeinrichPortland VA Health Care System, Portland, OR 97239, USA.ORCID 0000-0003-3790-0478
Sebastian BauerDepartment of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, 45147, Germany.ORCID 0000-0001-5949-8120

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Regulation of oncogenic KIT by LMTK3I01BX000338 · VA · PORTLAND VA MEDICAL CENTER · PI HEINRICH, MICHAEL C · 2009 to 2019
–
Functional profiling of germline SDH variants associated with cancer susceptibilityI01BX005358 · VA · PORTLAND VA MEDICAL CENTER · PI HEINRICH, MICHAEL C · 2021 to 2025
–
BLRD VA I01 BX000338BLRD VA I01 BX005358Deciphera PharmaceuticalsNCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Somatic

Indexed as

ExonsGastrointestinal Stromal TumorsMutationProto-Oncogene Proteins c-kitSunitinibAdultAgedAntineoplastic AgentsClinical Trials, Phase III as TopicDrug Resistance, NeoplasmFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedNaphthyridinesAntineoplastic AgentsKIT protein, humanNaphthyridinesProtein Kinase InhibitorsProto-Oncogene Proteins c-kitripretinibSunitinibUreactDNA mutational analysisgastrointestinal stromal tumorINSIGHTKIT mutationsPhase III trialpredictive markerripretinibsunitinibtargeted therapytyrosine kinase inhibitor

Identifiers

PMID39229786
PMCPMC11497949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.