ArticleArthritis & rheumatology (Hoboken, N.J.)2025
Do Existing Magnetic Resonance Imaging Definitions of Knee Osteoarthritis Identify Knees That Will Develop Clinically Significant Disease Over Up To 11 Years of Follow-Up?
Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Lower patella-patellar tendon angle is associated with increased odds of patellofemoral osteoarthritis progression in ACL revision patients: A case control study.Journal of experimental orthopaedics · 2026Article
- Rethinking early-stage knee osteoarthritis beyond radiography.Nature reviews. Rheumatology · 2026Article
- Knee Osteoarthritis on MRI in Symptomatic Young Adults After ACL Reconstruction From the SUPER-Knee Trial: Feature Prevalence and Association With Early-Stage Clinical Osteoarthritis Criteria.Orthopaedic journal of sports medicine · 2026Article
- Multimodality imaging considerations for genicular artery embolization in knee osteoarthritis.World journal of radiology · 2026Review
- Histological analysis of age-related degeneration in human female and male knee cartilage and meniscus.Osteoarthritis and cartilage open · 2026Article
- Magnetic resonance imaging-defined knee osteoarthritis rarely occurs without cartilage damage.Osteoarthritis and cartilage open · 2026Article
- Exploring Centrosome Amplification-Associated Biomarkers in Osteoarthritis Through Bioinformatics and Experimental Approaches.Journal of inflammation research · 2026Article
- Standard knee radiographs enable deep learning inference of MRI-defined cartilage and meniscal damage in early knee osteoarthritis: a study using the osteoarthritis initiative database.Frontiers in physiology · 2026Article
- Osteoarthritis: Magnetic resonance imaging definitions and disease progression: comment on the article by Chang et al.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveIn individuals without radiographic knee osteoarthritis (OA), we investigated whether magnetic resonance imaging (MRI)-defined knee OA at baseline was associated with incident radiographic and symptomatic disease during up to 11 years of follow-up.
methodsOsteoarthritis Initiative participants without tibiofemoral radiographic knee OA at baseline were assessed for MRI-based tibiofemoral cartilage damage, osteophyte presence, bone marrow lesions, and meniscal damage/extrusion. We defined MRI knee OA using alternative, reported definitions (Def A and Def B). Kellgren-Lawrence (KL) grade, joint space narrowing (JSN), and frequent knee symptoms (Sx) were assessed at baseline, 1-, 2-, 3-, 4-, 6-, 8-, and 10/11-year follow-up visits. Incident tibiofemoral radiographic knee OA (outcome) was defined as (1) KL ≥2, (2) KL ≥2 and JSN, or (3) KL ≥2 and Sx. Adjusted Cox proportional hazards regression models examined associations of baseline MRI-defined knee OA (Def A and Def B) with incident outcomes during up to 11 years of follow-up.
resultsAmong 1,621 participants (mean ± SD age 58.8 ± 9.0 years, mean ± SD body mass index 27.2 ± 4.5 kg/m
conclusionCurrent MRI definitions of knee OA do not adequately identify knees that will develop radiographic and symptomatic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.