Evidence map›Paper›PMID 39229325›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Impairments in knowledge of social norms in presymptomatic, prodromal, and symptomatic frontotemporal dementia.

Liset de Boer, Esther van den Berg, Jackie M Poos, Willeke Klop, Lucia A A Giannini, Julie F H De Houwer, Harro Seelaar, Lize C Jiskoot

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Liset de BoerDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.ORCID https://orcid.org/0009-0007-7161-3559
Esther van den BergDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Jackie M PoosDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Willeke KlopDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Lucia A A GianniniDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Julie F H De HouwerDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Harro SeelaarDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.
Lize C JiskootDepartment of Neurology and Alzheimer Center Erasmus MC University Medical Center Rotterdam the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe aimed to assess the knowledge of social norms in patients with behavioral variant frontotemporal dementia (bvFTD) with the Dutch version of the Social Norms Questionnaire (SNQ-NL).

methodsThe SNQ-NL was administered in 34 patients with bvFTD, 20 prodromal mutation carriers, 76 presymptomatic mutation carriers, and 56 controls. Group differences and correlations with other neuropsychological tests and gray matter volume were examined.

resultsPatients with bvFTD had lower total SNQ-NL scores and more over-adherence errors than presymptomatic mutation carriers and controls ( DISCUSSION: The SNQ-NL can identify impairments in knowledge of social norms in bvFTD, highlighting its significance in clinical diagnosis and upcoming clinical trials. The SNQ-NL currently fails to differentiate presymptomatic mutation carriers from controls; to this end, larger sample sizes from larger cohorts and longitudinal follow-up are warranted. Highlights: The Dutch version of the Social Norms Questionnaire (SNQ-NL) is able to detect impairment in social cognition in symptomatic bvFTD patients.A trend towards a lower performance in prodromal mutation carriers was found.Performance on the SNQ-NL is related to other measures of social cognition, executive functioning, and language.Lower SNQ-NL performance is related to gray matter volume loss in bilateral frontal and temporal regions.The SNQ-NL provides insight into the underlying cause of deficits in social cognition in bvFTD.

Indexed as

cognitionfrontotemporal dementianeuropsychological assessmentpresymptomaticprodromal

Identifiers

PMID39229325
PMCPMC11369490

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.