Evidence map›Paper›PMID 39229323›Full record

ReviewGenes & diseases2024

Novel perspectives on leptin in osteoarthritis: Focus on aging.

Zimo Liu, Wenqing Xie, Hengzhen Li, Xu Liu, Yao Lu, Bangbao Lu, Zhenhan Deng, Yusheng Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  17. Modulation of senescent LeprStem cell research & therapy · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zimo LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Wenqing XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Hengzhen LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xu LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yao LuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Bangbao LuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zhenhan DengDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Yusheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability and impaired quality of life, particularly among the elderly. Leptin, a 16-kD non-glycosylated protein encoded by the obese gene, is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee. The metabolic mechanisms employed by leptin in OA development have been widely studied, with attention being paid to aging as a corroborative risk factor for OA. Hence, in this review, we have attempted to establish a potential link between leptin and OA, by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mechanisms of OA that may provide fruitful guidance and emphasis for future research.

Indexed as

AgingArticular chondrocytesCellular senescenceDegenerationLeptinOsteoarthritis

Identifiers

PMID39229323
PMCPMC11369483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.