ArticleFrontiers in surgery2024
Butyrylcholinesterase levels correlate with surgical site infection risk and severity after colorectal surgery: a prospective single-center study.
Article in Frontiers in surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 6 of them syntheses that pooled it.
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Who cites it
109 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Risk factors for surgical site infections following cesarean section in Ethiopia: umbrella review.BMC pregnancy and childbirth · 2026Pooled it
- A validated predictive model for mid- and long-term mortality risk assessment after elective endovascular repair in abdominal aortic aneurysm patients.Annals of medicine · 2025Pooled it
- Differences in the rates of seroma complications between hernial sac transection and reduction after laparoscopic inguinal hernia repair: systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Bibliometric analysis of preoperative radiotherapy for locally advanced rectal cancer: evolution and future.Frontiers in medicine · 2025Pooled it
- A systematic review on the techniques, long-term outcomes, and complications of partial breast irradiation after breast-conserving surgery for early-stage breast cancer.Scientific reports · 2024Pooled it
- Effect of preoperative hair removal vs. no removal on surgical site infections: a systematic review and meta-analysis.F1000Research · 2024Pooled it
- Underwater endoscopic mucosal resection is superior to conventional endoscopic mucosal resection for medium-sized colorectal sessile polyps: a randomized controlled trial.Scientific reports · 2024Trial
- Socioeconomic disparities in survival of patients with superficial colorectal cancer.Discover oncology · 2026Article
- Protective Effect of Prophylactic Negative-Pressure Wound Therapy on Surgical-Site Infection in High-Risk Open Abdominal Surgery: A Retrospective Cohort Study and Nomogram Development.International wound journal · 2026Article
- Emergency Surgery and the Risk of Anastomotic Leakage After Colorectal Resection with Primary Anastomosis for Benign and Malignant Disease: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Development and Internal Validation of a Novel Prognostic Score in Metastatic Colorectal Cancer: A Comparative Retrospective Cohort Study with the Glasgow Prognostic Score and Gustave Roussy Immune Score.Journal of clinical medicine · 2026Article
- Cumulative Surgeon Experience and Anastomotic Leakage After Left-Sided and Segmental Colorectal Resection with Primary Anastomosis: A Seven-Year Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Ten-Year Outcomes in Colorectal Cancer-Competing Risks and Patient Vulnerability: A Prospective Multicenter Observational Study.Journal of clinical medicine · 2026Article
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- Is the Lactate/Albumin Ratio Associated with 28-Day Mortality in Critically Ill Patients That Underwent Open Gastric Cancer Surgery? A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Cefiderocol in Children with Hematologic Malignancies-The Multicenter Retrospective Experience of the Infection Working Group of the Italian Pediatric Hematology and Oncology Association (AIEOP).Journal of clinical medicine · 2026Article
- Predictors of Postoperative Complications After Retromuscular Incisional Hernia Repair: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- The Adjunctive Role of Dynamic Systemic Inflammation-Based Biomarkers in Surgical Risk Stratification of First-Episode Primary Spontaneous Pneumothorax.Diagnostics (Basel, Switzerland) · 2026Article
- The Impact of Obesity on Operative Outcomes and Long-Term Oncological Outcomes Following Rectal Cancer Surgery: A Retrospective Single-Center Study.Journal of clinical medicine · 2026Article
- Article
49 more citing papers are in PubMed but not listed here.
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Abstract
Introduction: Surgical site infections (SSIs) after colorectal surgery remain a significant concern, which warrants effective predictive markers for prompt diagnosis and treatment. Butyrylcholinesterase (BChE), a non-specific cholinesterase enzyme, has been correlated with the risk of hepatic dysfunction progression and, more recently, infectious diseases and septic shock with ongoing research into the utility of BChE in multiple systemic inflammatory conditions. Whether these preliminary results can be translated into predicting infection after colorectal surgery remains in remains in question. This prospective study aimed to assess BChE's potential as a predictive marker for surgical site infections and anastomotic leaks after colorectal surgery. Materials and methods: This single-center prospective study (11/2019-05/2023) enrolled 402 patients who underwent colorectal surgery. BChE levels were measured at four postoperative time points. The primary endpoints focused on BChE's association with complications, particularly surgical site infections (SSIs). Further known predictors of SSI were utilized to construct multivariable models to assess for independent association with SSI development. Results: During the third and fifth day postsurgery, SSI patients had significantly lower mean BChE levels (3.90 KU/L vs. 4.54 KU/L Conclusion: In conclusion, in this prospective observational study, low levels in the first and third postsurgery were associated with an increased risk for the development of SSIs but not sepsis.
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