Evidence map›Paper›PMID 39229223›Full record

ArticlebioRxiv : the preprint server for biology2024

Chronic innate immune impairment and ZIKV persistence in the gastrointestinal tract during SIV infection in pigtail macaques.

Jennifer Tisoncik-Go, Thomas B Lewis, Leanne S Whitmore, Kathleen Voss, Skyler Niemeyer, Jin Dai, Paul Kim, Kai Hubbell, Naoto Iwayama, Chul Ahrens and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jennifer Tisoncik-GoWashington National Primate Research Center, University of Washington (Seattle, Washington).
Thomas B LewisWashington National Primate Research Center, University of Washington (Seattle, Washington).
Leanne S WhitmoreDepartment of Immunology, University of Washington (Seattle, Washington).
Kathleen VossWashington National Primate Research Center, University of Washington (Seattle, Washington).
Skyler NiemeyerDepartment of Microbiology, University of Washington (Seattle, Washington).
Jin DaiDepartment of Immunology, University of Washington (Seattle, Washington).
Paul KimDepartment of Microbiology, University of Washington (Seattle, Washington).
Kai HubbellDepartment of Microbiology, University of Washington (Seattle, Washington).
Naoto IwayamaWashington National Primate Research Center, University of Washington (Seattle, Washington).
Chul AhrensWashington National Primate Research Center, University of Washington (Seattle, Washington).
Solomon WangariWashington National Primate Research Center, University of Washington (Seattle, Washington).
Robert MurnaneWashington National Primate Research Center, University of Washington (Seattle, Washington).
Paul T EdlefsenFred Hutchinson Cancer Center (Seattle, Washington).
Kathryn A GuerrieroWashington National Primate Research Center, University of Washington (Seattle, Washington).
Michael GaleWashington National Primate Research Center, University of Washington (Seattle, Washington).
Deborah H FullerWashington National Primate Research Center, University of Washington (Seattle, Washington).
Megan A O'ConnorWashington National Primate Research Center, University of Washington (Seattle, Washington).ORCID 0000-0003-2127-5073

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI Melissa R Berg, Cindy Buckmaster · 2012 to 2026
$34.4M
Urethral microbiome and non-gonococcal urethritis in men who have sex with men (MU19AI113173 · NIAID · UNIVERSITY OF WASHINGTON · PI HUGHES, JAMES P · 2014 to 2018
$14.3M
Innate Immune Regulation of Zika Virus InfectionR01AI145296 · NIAID · UNIVERSITY OF WASHINGTON · PI COYNE, CAROLYN B, DIAMOND, MICHAEL S · 2019 to 2023
$4.1M
Evaluating risks of ZIKV co-infection in SIV-infected macaquesK01MH123258 · NIMH · UNIVERSITY OF WASHINGTON · PI O'CONNOR, MEGAN A · 2020 to 2022
$346k
NCATS NIH HHS UL1 TR000423NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI145296NIAID NIH HHS U19 AI113173NIH HHS P51 OD010425NIH HHS U42 OD011123NIMH NIH HHS K01 MH123258
6 · The paper itself

Abstract

Mosquito borne flaviviruses, including dengue (DENV) and Zika (ZIKV) viruses, have caused global epidemics in areas with high HIV prevalence due to the expanded geographic range of arthropod vectors. Despite the occurrence of large flavivirus outbreaks in countries with high HIV prevalence, there is little knowledge regarding the effects of flavivirus infection in people living with HIV (PLWH). Here, we use a pigtail macaque model of HIV/AIDS to investigate the impact of simian immunodeficiency virus (SIV)-induced immunosuppression on ZIKV replication and pathogenesis. Early acute SIV infection induced expansion of peripheral ZIKV cellular targets and increased innate immune activation and peripheral blood mononuclear cells (PBMC) from SIV infected macaques were less permissive to ZIKV infection

Identifiers

PMID39229223
PMCPMC11370579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.