Evidence map›Paper›PMID 39229203›Full record

ArticlebioRxiv : the preprint server for biology2025

Cell Geometry and Membrane Protein Crowding Constrain Growth Rate, Overflow Metabolism, Respiration, and Maintenance Energy.

Ross P Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, William R Harcombe, Radhakrishnan Mahadevan, Ashley E Beck

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ross P CarlsonDepartment of Chemical and Biological Engineering, Center for Biofilm Engineering, Montana State University, Bozeman, MT USA.ORCID 0000-0002-2464-7111
Tomáš GedeonDepartment of Mathematical Sciences, Montana State University, Bozeman, MT USA.
Mauricio Garcia BenitezDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Canada.
William R HarcombeDepartment of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN USA.
Radhakrishnan MahadevanDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Canada.
Ashley E BeckDepartment of Biological and Environmental Sciences, Carroll College, Helena, MT USA.

Funding

Predictive Multiscale Modeling of Microbial Consortia BiofilmsU01EB019416 · NIBIB · MONTANA STATE UNIVERSITY - BOZEMAN · PI CARLSON, ROSS P., FIELDS, MATTHEW W · 2014 to 2017
$1.3M
NIBIB NIH HHS U01 EB019416
6 · The paper itself

Abstract

A metabolic theory is presented for predicting maximum growth rate, overflow metabolism, respiration efficiency, and maintenance energy flux based on the intersection of cell geometry, membrane protein crowding, and metabolism. The presented membrane-centric theory employs biophysical properties and metabolic systems analysis to successfully predict phenotypic properties of

Indexed as

cell biologycell geometrymetabolismsurface area to volume ratiosystems biology

Identifiers

PMID39229203
PMCPMC11370460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.