Evidence map›Paper›PMID 39229145›Full record

ArticlebioRxiv : the preprint server for biology2024

Nageotte nodules in human DRG reveal neurodegeneration in painful diabetic neuropathy.

Stephanie I Shiers, Khadijah Mazhar, Andi Wangzhou, Rainer Haberberger, Joseph B Lesnak, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Anna Cervantes, Geoffrey Funk, Peter Horton and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Stephanie I ShiersDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.ORCID 0000-0002-9646-1850
Khadijah MazharDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.
Andi WangzhouDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.
Rainer HaberbergerSchool of Biomedicine, The University of Adelaide, Australia.
Joseph B LesnakDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.
Ishwarya SankaranarayananDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.
Diana Tavares-FerreiraDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.ORCID 0000-0003-0986-3630
Anna CervantesSouthwest Transplant Alliance.
Geoffrey FunkSouthwest Transplant Alliance.
Peter HortonSouthwest Transplant Alliance.
Erin VinesSouthwest Transplant Alliance.
Gregory DussorDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.
Theodore J PriceDepartment of Neuroscience, Center for Advanced Pain Studies, The University of Texas at Dallas. Richardson, TX.ORCID 0000-0002-6971-6221

Funding

Anatomic, Physiologic and Transcriptomic Mechanisms of Neuropathic Pain in Human DRGR01NS111929 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DOUGHERTY, PATRICK M, PRICE, THEODORE J. · 2020 to 2024
$3.4M
NINDS NIH HHS R01 NS111929
6 · The paper itself

Abstract

Diabetic neuropathy is frequently accompanied by pain and loss of sensation attributed to axonal dieback. We recovered dorsal root ganglia (DRGs) from 90 organ donors, 19 of whom had medical indices for diabetic painful neuropathy (DPN). Nageotte nodules, dead sensory neurons engulfed by non-neuronal cells, were abundant in DPN DRGs and accounted for 25% of all neurons. Peripherin-and Nav1.7-positive dystrophic axons invaded Nageotte nodules, forming small neuroma-like structures. Using histology and spatial sequencing, we demonstrate that Nageotte nodules are mainly composed of satellite glia and non-myelinating Schwann cells that express

Identifiers

PMID39229145
PMCPMC11370606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.