ArticlebioRxiv : the preprint server for biology2024
Sex differences in nucleus accumbens core circuitry engaged by binge-like ethanol drinking.
Amy E Chan, Justin Q Anderson, Kolter B Grigsby, Bryan E Jensen, Andrey E Ryabinin, Angela R Ozburn
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Amy E ChanOregon Health and Science University, Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, OR, 97239, USA.ORCID 0000-0002-7362-4936 Justin Q AndersonOregon Health and Science University, Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, OR, 97239, USA.
Kolter B GrigsbyOregon Health and Science University, Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, OR, 97239, USA.
Bryan E JensenVeterans Affairs Portland Health Care System, Research and Development Service, Portland, OR, 97239, USA.
Andrey E RyabininOregon Health and Science University, Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, OR, 97239, USA.
Angela R OzburnOregon Health and Science University, Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, Portland, OR, 97239, USA.
Funding
Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAMARA J. PHILLIPS · 2006 to 2026
$34.5MBIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3MSelective Breeding for Drinking in the Circadian DarkU01AA013519 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Angela Renee Ozburn · 2001 to 2026
$10.9MTHERMAL AND METABOLIC DYSFUNCTION DURING WITHDRAWALP50AA010760 · NIAAA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI CRABBE, JOHN C. · 1996 to 2005
$10.7MSensitivity and resilience to increased alcohol drinking in males and females following traumatic stressR01AA028680 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI RYABININ, ANDREY E · 2020 to 2024
$1.9MCenter for Underrepresented Research in Addiction (CURA)R25DA050727 · NIDA · LOYOLA UNIVERSITY CHICAGO · PI TORRES, GONZALO E. · 2019 to 2024
$1.3MA circuit-driven evaluation of the use of physical activity interventions to improve binge-like ethanol drinkingR00AA030806 · NIAAA · WASHINGTON STATE UNIVERSITY · PI Kolter Bill Grigsby · 2025 to 2026
$482kA circuit-driven evaluation of the use of physical activity interventions to improve binge-like ethanol drinkingK99AA030806 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI GRIGSBY, KOLTER · 2023 to 2024
$371kRole of nucleus accumbens core in ethanol reward and binge-like drinking: Focus on sex as a biological variableF31AA030908 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI CHAN, AMY ELIZABETH · 2023 to 2025
$119kBLRD VA I01 BX004699BLRD VA I01 BX006570NIAAA NIH HHS F31 AA030908NIAAA NIH HHS K99 AA030806NIAAA NIH HHS P50 AA010760NIAAA NIH HHS P60 AA010760NIAAA NIH HHS R00 AA030806NIAAA NIH HHS R01 AA028680NIAAA NIH HHS T32 AA007468NIAAA NIH HHS U01 AA013519NIDA NIH HHS R25 DA050727
6 · The paper itselfAbstract
Growing parity in Alcohol Use Disorder (AUD) diagnoses in men and women necessitates consideration of sex as a biological variable. In humans and rodents, the nucleus accumbens core (NAcc) regulates alcohol binge drinking, a risk factor for developing AUD. We labeled NAcc inputs with a viral retrograde tracer and quantified whole-brain c-Fos to determine the regions and NAcc inputs differentially engaged in male and female mice during binge-like ethanol drinking. We found that binge-like ethanol drinking females had 129 brain areas with greater c-Fos than males. Moreover, ethanol engaged more NAcc inputs in binge-like ethanol drinking females (as compared with males), including GABAergic and glutamatergic inputs. Relative to water controls, ethanol increased network modularity and decreased connectivity in both sexes and did so more dramatically in males. These results demonstrate that early-stage binge-like ethanol drinking engages brain regions and NAcc-inputs and alters network dynamics in a sex-specific manner.
Identifiers
PMID39229134
PMCPMC11370393
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