Evidence map›Paper›PMID 39229044›Full record

ArticlebioRxiv : the preprint server for biology2024

Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension.

Ronghao Zhang, Shujie Shi, Darshan Aatmaram Jadhav, Najeong Kim, Autumn Brostek, Beau R Forester, Rashi Shukla, Christina Qu, Benjamin Kramer, Jeffrey L Garvin and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Shujie Shi
Darshan Aatmaram JadhavORCID 0009-0001-0997-5491
Najeong Kim
Rashi Shukla
Christina Qu
Benjamin Kramer
Jeffrey L Garvin
Agustin Gonzalez-VicenteORCID 0000-0002-3682-0815

Funding

Using transcriptomics and ex vivo organotypic models to discover mechanisms of APOL1-associated podocytopathiesK01DK128304 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Agustin Gonzalez-Vicente · 2023 to 2026
$524k
6 · The paper itself

Abstract

Fructose high-salt (FHS) diets increase blood pressure (BP) in an angiotensin II (Ang II)-dependent manner. Ang II stimulates aldosterone release, which, by acting on the mineralocorticoid receptor (MR), regulates Na

Identifiers

PMID39229044
PMCPMC11370327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.