Evidence map›Paper›PMID 39229042›Full record

ArticlebioRxiv : the preprint server for biology2024

Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture.

Vinod Kumar Reddy Lekkala, Sunil Shrestha, Ayah Al Qaryoute, Sanchi Dhinoja, Prabha Acharya, Abida Raheem, Pudur Jagadeeswaran, Moo-Yeal Lee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Vinod Kumar Reddy LekkalaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Sunil ShresthaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Ayah Al QaryouteDepartment of Biological Sciences, University of North Texas, Denton, TX, USA.
Sanchi DhinojaDepartment of Biological Sciences, University of North Texas, Denton, TX, USA.
Prabha AcharyaDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Abida RaheemDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.
Pudur JagadeeswaranDepartment of Biological Sciences, University of North Texas, Denton, TX, USA.
Moo-Yeal LeeDepartment of Biomedical Engineering, University of North Texas, Denton, Texas, USA.ORCID 0000-0001-6922-609X

Funding

Modeling diabetes using an integrated plate systemUH3DK119982 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE, MOO-YEAL, WELLS, JAMES M · 2020 to 2022
$5.4M
Regulators of von Willebrand Factor LevelsR01HL159399 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI JAGADEESWARAN, PUDUR · 2021 to 2023
$891k
Pillar and perfusion well plate platforms for reproducible organoid culture from iPSCR44TR003491 · NCATS · BIOPRINTING LABORATORIES, INC. · PI JOSHI, PRANAV, LEE, MOO-YEAL · 2020 to 2021
$838k
Gene-edited liver organoids for predictive hepatotoxicityR43ES035653 · NIEHS · BIOPRINTING LABORATORIES, INC. · PI JOSHI, PRANAV, LEE, MOO-YEAL · 2023 to 2023
$285k
NCATS NIH HHS R44 TR003491NHLBI NIH HHS R01 HL159399NIDDK NIH HHS UH3 DK119982NIEHS NIH HHS R43 ES035653
6 · The paper itself

Abstract

Liver tissues, composed of hepatocytes, cholangiocytes, stellate cells, Kupffer cells, and sinusoidal endothelial cells, are differentiated from endodermal and mesodermal germ layers. By mimicking the developmental process of the liver, various differentiation protocols have been published to generate human liver organoids (HLOs)

Indexed as

coagulation factor secretiondeep well plateenhanced organoid maturitypillar plateVascular human liver organoids

Identifiers

PMID39229042
PMCPMC11370572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.