Evidence map›Paper›PMID 39229041›Full record

ArticlebioRxiv : the preprint server for biology2024

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.

Yuning J Tang, Haiqing Xu, Nicholas W Hughes, Samuel H Kim, Paloma Ruiz, Emily G Shuldiner, Steven S Lopez, Jess D Hebert, Saswati Karmakar, Laura Andrejka and 12 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Yuning J Tang
Haiqing Xu
Nicholas W Hughes
Samuel H Kim
Paloma Ruiz
Emily G Shuldiner
Steven S Lopez
Saswati Karmakar
Laura Andrejka
D Nesli Dolcen
Gabor Boross
Pauline Chu
Colin Detrick
Sarah Pierce
Emily L Ashkin
William J Greenleaf
Anne K Voss
Tim Thomas
Matt van de Rijn
Dmitri A Petrov
Monte M Winslow

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
Genetic analysis of aging on immune responses to lung cancerU01AG077922 · NIA · STANFORD UNIVERSITY · PI WINSLOW, MONTE MEIER · 2021 to 2025
$2.5M
Genetic dissection of oncogenic Kras signalingR01CA230025 · NCI · STANFORD UNIVERSITY · PI WINSLOW, MONTE MEIER · 2021 to 2025
$2.2M
NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA230025NIA NIH HHS U01 AG077922
6 · The paper itself

Abstract

Epigenetic dysregulation is widespread in cancer. However, the specific epigenetic regulators and the processes they control to drive cancer phenotypes are poorly understood. Here, we employed a novel, scalable and high-throughput

Identifiers

PMID39229041
PMCPMC11370414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.