Evidence map›Paper›PMID 39229027›Full record

ArticlebioRxiv : the preprint server for biology2025

Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex.

Nelson J Johansen, Niklas Kempynck, Nathan R Zemke, Saroja Somasundaram, Seppe De Winter, Marcus Hooper, Deepanjali Dwivedi, Ruchi Lohia, Fabien Wehbe, Bocheng Li and 24 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Nelson J JohansenAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0002-4436-969X
Niklas KempynckVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-0104-4844
Nathan R ZemkeCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-6326-5925
Saroja SomasundaramAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0002-3729-9849
Seppe De WinterVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0001-7907-1247
Marcus HooperAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0003-1228-5958
Deepanjali DwivediAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0001-9992-9167
Ruchi LohiaPhysiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3496-8197
Fabien WehbeMaisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.ORCID 0000-0001-9359-1855
Bocheng LiSchool of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Darina AbaffyováVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-0636-517X
Ethan J ArmandBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-4516-6317
Julie De ManVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0009-0003-7208-8961
Eren Can EksiVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-3122-9858
Nikolai HeckerVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0003-1693-4257
Gert HulselmansVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0003-2205-1899
Vasilis KonstantakosVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-0332-7506
David MauduitVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-2045-227X
John K MichAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0002-1626-1139
Gabriele PartelVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-4482-3119
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0001-9700-8452
Boaz P LeviAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0002-8346-872X
Kai ZhangSchool of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.ORCID 0000-0003-3454-7357
Yoshiaki TanakaMaisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.ORCID 0000-0002-2078-9374
Jesse GillisPhysiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0936-9774
Jonathan T TingAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0001-8266-0392
Yoav Ben-SimonAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0002-7075-097X
Jeremy MillerAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0003-4549-588X
Joseph R EckerSalk Institute for Biological Studies, La Jolla, CA 92037.ORCID 0000-0001-5799-5895
Bing RenCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-5435-1127
Stein AertsVIB Center for AI & Computational Biology, VIB-KU Leuven Center for Brain and Disease Research & KU Leuven Department of Human Genetics, Leuven, Belgium.ORCID 0000-0002-8006-0315
Ed S LeinAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0001-9012-6552
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0002-6861-4506
Trygve E BakkenAllen Institute for Brain Science, Seattle, WA 98109.ORCID 0000-0003-3373-7386

Funding

Open-Access AAV Toolbox for Basal Ganglia Cell Types and CircuitsUF1MH128339 · NIMH · ALLEN INSTITUTE · PI BAKKEN, TRYGVE, DAIGLE, TANYA LYNN · 2021 to 2021
$7.3M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
Development of tools for cell-type specific labeling of human and mouse neocortical neuronsRF1MH114126 · NIMH · ALLEN INSTITUTE · PI LEIN, ED, LEVI, BOAZ PIRIE · 2017 to 2017
$4.5M
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitryUG3MH120095 · NIMH · ALLEN INSTITUTE · PI KALUME, FRANCK K, LEIN, ED · 2020 to 2022
$3.8M
Cell class- or type-specific viruses for brain-wide labeling and neural circuit examinationRF1MH121274 · NIMH · ALLEN INSTITUTE · PI TASIC, BOSILJKA · 2019 to 2019
$2.6M
Revealing the transcriptomic basis of neuronal identity through functional meta-analysisR01MH113005 · NIMH · COLD SPRING HARBOR LABORATORY · PI GILLIS, JESSE · 2017 to 2021
$2.4M
NHGRI NIH HHS UM1 HG011585NIMH NIH HHS R01 MH113005NIMH NIH HHS RF1 MH114126NIMH NIH HHS RF1 MH121274NIMH NIH HHS UF1 MH128339NIMH NIH HHS UG3 MH120095
6 · The paper itself

Abstract

Identifying cell type-specific enhancers in the brain is critical to building genetic tools for investigating the mammalian brain. Computational methods for functional enhancer prediction have been proposed and validated in the fruit fly and not yet the mammalian brain. We organized the 'Brain Initiative Cell Census Network (BICCN) Challenge: Predicting Functional Cell Type-Specific Enhancers from Cross-Species Multi-Omics' to assess machine learning and feature-based methods designed to nominate enhancer DNA sequences to target cell types in the mouse cortex. Methods were evaluated based on

Indexed as

AAVATAC-seqbenchmarkcell typeschallengecortexDNA methylationenhancerHiCmachine learningmousemultiomeprimatesRNA-Seq

Identifiers

PMID39229027
PMCPMC11370467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.