Evidence map›Paper›PMID 39229024›Full record

ArticlebioRxiv : the preprint server for biology2024

Engineering Planar Gram-Negative Outer Membrane Mimics Using Bacterial Outer Membrane Vesicles.

Aarshi N Singh, Meishan Wu, Tiffany T Ye, Angela C Brown, Nathan J Wittenberg

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Aarshi N SinghDepartment of Chemistry, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0002-5888-4449
Meishan WuDepartment of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.
Tiffany T YeDepartment of Chemistry, Lehigh University, Bethlehem, PA, USA.
Angela C BrownDepartment of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0003-1038-8216
Nathan J WittenbergDepartment of Chemistry, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0001-9196-1867

Funding

Elucidating the membrane properties regulating antimicrobial peptidebinding to bacterial vesiclesR15GM152918 · NIGMS · LEHIGH UNIVERSITY · PI WITTENBERG, NATHAN J. · 2023 to 2023
$457k
Microfluidic nanoarrays for high-throughput analysis of biological nanostructuresR21GM134414 · NIGMS · LEHIGH UNIVERSITY · PI WITTENBERG, NATHAN J. · 2019 to 2020
$409k
Controlled antibiotic delivery vehicle for treatment of aggressiveperiodontitisR21DE032153 · NIDCR · LEHIGH UNIVERSITY · PI BROWN, ANGELA C. · 2023 to 2024
$408k
NIDCR NIH HHS R21 DE032153NIGMS NIH HHS R15 GM152918NIGMS NIH HHS R21 GM134414
6 · The paper itself

Abstract

Antibiotic resistance is a major challenge in modern medicine. The unique double membrane structure of gram-negative bacteria limits the efficacy of many existing antibiotics and adds complexity to antibiotic development by limiting transport of antibiotics to the bacterial cytosol. New methods to mimic this barrier would enable high-throughput studies for antibiotic development. In this study, we introduce an innovative approach to modify outer membrane vesicles (OMVs) from

Indexed as

Aggregatibacter actinomycetemcomitansantibiotic developmentGram-negative bacteriamodel membraneouter membrane vesicles

Identifiers

PMID39229024
PMCPMC11370475

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.