In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Nathan C WinnDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-5276-0592 Deborah A RobyDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-6392-177X P Mason McClatcheyDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-6187-3273 Ian M WilliamsDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.
Deanna P BracyDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.
Michelle N BedenbaughDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.
Louise LantierDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-6620-4976 Ambra PozziDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-8502-1481 David H WassermanDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-3095-2665 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Marcela Brissova · 2012 to 2026
$29.3MThe Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5MINTEGRATED CONTROL OF MUSCLE GLUCOSE UPTAKE IN VIVOR01DK054902 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 1999 to 2020
$5.9MRole of the Cell Adhesome in Obesity-related Liver DiseasesR01DK050277 · NIDDK · VANDERBILT UNIVERSITY · PI MCGUINNESS, OWEN P · 1995 to 2023
$4.8MIntegrins in the Developing LungR01HL163195 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Erin J Plosa · 2022 to 2026
$3.1MMatrix receptors in chronic kidney diseaseR01DK119212 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BORZA, CORINA MARILENA, POZZI, AMBRA · 2018 to 2022
$1.7MUncovering mechanisms of pancreatic adaptability to weight cyclingK01DK136926 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Nathan C Winn · 2023 to 2026
$535kBLR&D Merit Review Research Career Scientist (RCS) Award (IK6)IK6BX005240 · VA · VETERANS HEALTH ADMINISTRATION · PI POZZI, AMBRA · 2020 to 2025
–The ILK/PINCH/Parvin complex in renal tubulogenesisI01BX002196 · VA · VETERANS HEALTH ADMINISTRATION · PI ZENT, ROY · 2013 to 2025
–Role of Collagen Binding Receptors in GlomerulosclerosisI01BX002025 · VA · VETERANS HEALTH ADMINISTRATION · PI AMBRA POZZI · 2013 to 2026
–BLRD VA I01 BX002025BLRD VA I01 BX002196BLRD VA IK6 BX005240NCI NIH HHS P30 CA068485NHLBI NIH HHS R01 HL163195NIDDK NIH HHS K01 DK136926NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK050277NIDDK NIH HHS R01 DK054902NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK119212
6 · The paper itselfAbstract
Microvascular insulin delivery to myocytes is rate limiting for the onset of insulin-stimulated muscle glucose uptake. The structural integrity of capillaries of the microvasculature is regulated, in part, by a family of transmembrane adhesion receptors known as integrins, which are composed of an α and β subunit. The integrin β1 (itgβ1) subunit is highly expressed in endothelial cells (EC). EC itgβ1 is necessary for the formation of capillary networks during embryonic during development and its knockdown in adult mice blunts the reactive hyperemia that manifests during ischemia reperfusion. In this study we investigated the contribution of skeletal muscle EC itgβ1 in microcirculatory function and glucose uptake. We hypothesized that loss of EC itgβ1 would impair microvascular hemodynamics and glucose uptake during insulin stimulation, creating 'delivery'-mediated insulin resistance. An itgβ1 knockdown mouse model was developed to avoid lethality of embryonic gene knockout and the deteriorating health resulting from early post-natal inducible gene deletion. We found that mice with (itgβ1
Identifiers
PMID39229013
PMCPMC11370432
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390