Evidence map›Paper›PMID 39229005›Full record

ArticlebioRxiv : the preprint server for biology2024

High-throughput affinity measurements of direct interactions between activation domains and co-activators.

Nicole DelRosso, Peter H Suzuki, Daniel Griffith, Jeffrey M Lotthammer, Borna Novak, Selin Kocalar, Maya U Sheth, Alex S Holehouse, Lacramioara Bintu, Polly Fordyce

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole DelRossoBiophysics Program, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4339-3353
Peter H SuzukiDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6108-0273
Daniel GriffithDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9633-9601
Jeffrey M LotthammerDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5022-7006
Borna NovakDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Selin KocalarDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-4521-8647
Maya U ShethDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Alex S HolehouseDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-4155-5729
Lacramioara BintuBiophysics Program, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5443-6633
Polly FordyceBiophysics Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9505-0638

Funding

High-throughput development and characterization of compact tools for transcriptional and chromatin perturbationsR01HG011866 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL C BASSIK, Lacramioara Bintu · 2021 to 2026
$6.9M
Single-cell analysis and synthetic control of mammalian chromatin dynamics and gene regulationR35GM128947 · NIGMS · STANFORD UNIVERSITY · PI Lacramioara Bintu · 2018 to 2026
$3.1M
Uncovering the regulatory logic of gene expression encoded by disordered regionsDP2CA290639 · NCI · WASHINGTON UNIVERSITY · PI Alex S Holehouse · 2023 to 2026
$2.3M
NCI NIH HHS DP2 CA290639NHGRI NIH HHS R01 HG011866NIGMS NIH HHS R35 GM128947
6 · The paper itself

Abstract

Sequence-specific activation by transcription factors is essential for gene regulation

Identifiers

PMID39229005
PMCPMC11370418

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.