ArticleFrontiers in public health2024
Association between serum and urinary environmental metal levels and major depressive disorder: a study based on logistic regression and quantile regression.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Magnesium Attenuates the Association Between Mixed Element Exposure and Depressive Symptoms in Older Adults.Toxics · 2026Article
- Association between heavy metals exposure and depression: findings of the NHANES from 2003 to 2020.European journal of medical research · 2026Article
- Factors associated with depressive disorders in college students using quantile regression analysis.BMC psychiatry · 2025Article
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Authors and funding
5 authors.
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Abstract
Background: Major depressive disorder (MDD) is a prevalent mental disorder globally. Increasing evidence suggests that Environmental Metal (EM) play a crucial role in MDD. Therefore, this study investigated the roles of barium (Ba), cesium (Cs), nickel (Ni), manganese (Mn), lead (Pb), mercury (Hg), cadmium (Cd), and tin (Sn) in the etiology of MDD. Methods: The study included 72 MDD patients and 75 healthy controls (HCs) from the Second People's Hospital of Zhumadian, China. Inductively coupled plasma mass spectrometer (ICP-MS) measured the metal levels in serum and urine samples from both groups. Results: Significant differences in serum and urine levels of EMs were observed between MDD patients and HCs. After adjusting for age, gender, and BMI, logistic regression and quantile regression models revealed significant associations between EMs and MDD. In serum samples, higher Sn levels (OR = 1.22, Conclusion: These findings underscore EMs' importance in depression, aiding in targeted interventions for varying degrees of depression and necessitating future studies to clarify causality and mechanisms.
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